Substitution of a mutant α_2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

Parul P. Lakhlani; Leigh B. MacMillan; Tian Zhi Guo

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Substitution of a mutant α_2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

机译：通过“命中和奔跑”基因靶向替代突变体α_2a-肾上腺素受体揭示了该亚型在体内的镇静，镇痛和麻醉剂缓解反应中的作用

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Norepinephrine contributes to antinocicep- tive, sedative, and sympatholytic responses in vivo, and α2 adrenergic receptor (α_2AR) agonists are used clinically to mimic these effects. Lack of subtype-specific agonists has prevented elucidation of the role that each α_2AR subtype (α_2A, α2B, and α_2C) plays in these central effects. Here we demon- strate that α_2AR agonist-elicited sedative, anesthetic-sparing, and analgesic responses are lost in a mouse line expressing a subtly mutated α_2A AR, D79N α_2A AR, created by two-step homologous recombination.

机译：去甲肾上腺素有助于体内的抗伤害性，镇静性和交感神经反应，临床上使用α2肾上腺素能受体（α_2AR）激动剂来模拟这些作用。缺乏亚型特异性激动剂无法阐明每种α_2AR亚型（α_2A，α2B和α_2C）在这些中心作用中的作用。在这里，我们证明了通过两步同源重组产生的α_2AR激动剂引起的镇静，麻醉保留和镇痛反应在表达微妙突变的α_2AAR，D79Nα_2AAR的小鼠品系中消失了。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第18期|p.9950-9955|共6页
作者
Parul P. Lakhlani; Leigh B. MacMillan; Tian Zhi Guo;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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5. Substitution of a mutant α2a-adrenergic receptor via hit and run gene targeting reveals the role of this subtype in sedative analgesic and anesthetic-sparing responses in vivo [O] . Parul P. Lakhlani, Leigh B. MacMillan, Tian Zhi Guo, 1997

机译：突变的α2a-肾上腺素能受体的替代通过命中即跑基因定位揭示了该亚型的作用体内的镇静镇痛和麻醉药反应
6. Substitution of a mutant 2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo [O] . P. P. Lakhlani, L. B. MacMillan, T. Z. Guo, 1997

机译：通过“击中和运行”基因靶向突变体2A-肾上腺素能受体旨在揭示该亚型在体内镇静，镇痛和麻醉剂的作用中的作用

Substitution of a mutant α_2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

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