Modulation of potassium channel function by methionine oxidation and reduction

Matthew A. Ciorba; Stefan H. Heinemann; Herbert Weissbach

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Modulation of potassium channel function by methionine oxidation and reduction

机译：通过蛋氨酸氧化和还原调节钾通道功能

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Oxidation of amino acid residues in proteins can be caused by a variety of oxidizing agents normally produced by cells. The oxidation of methionine in proteins to methionine sulfoxide is implicated in aging as well as in pathological conditions, and it is a reversible reaction medi- ated by a ubiquitous enzyme, peptide methionine sulfoxide reductase. The reversibility of methionine oxidation suggests that it could act as a cellular regulatory mechanism although no such in vivo activity has been demonstrated. We show here that oxidation of a methionine residue in a voltage-dependent potassium channel modulates its inactivation.

机译：蛋白质中氨基酸残基的氧化可以由细胞通常产生的多种氧化剂引起。蛋白质中蛋氨酸向蛋氨酸亚砜的氧化与衰老以及病理状况有关，这是一种普遍存在的可逆反应，它是一种普遍存在的酶，即肽蛋氨酸亚砜还原酶。蛋氨酸氧化的可逆性表明它可以作为细胞调节机制，尽管尚未证明这种体内活性。我们在这里显示，电压依赖性钾通道中甲硫氨酸残基的氧化调节其失活。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第18期|p.9932-9937|共6页
作者
Matthew A. Ciorba; Stefan H. Heinemann; Herbert Weissbach;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Functional consequences of methionine oxidation of hERG potassium channels. [J] . Su Z, Limberis J, Martin RL, Biochemical Pharmacology . 2007,第5期

机译：hERG钾通道蛋氨酸氧化的功能后果。
2. The methionine sulfoxide reduction system: Selenium utilization and methionine sulfoxide reductase enzymes and their functions [J] . KimH.-Y. Antioxidants and redox signalling . 2013,第9期

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3. Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth [J] . Pascal Mariot, Philippe Delcourt, Natalia Prevarskaya, Biology Open . 2013,第9期

机译：大传导钾通道和Cav3.2电压依赖性钙通道之间的功能偶联参与前列腺癌细胞的生长大传导钾通道和Cav3.2电压依赖性钙通道之间的功能偶联参与前列腺癌细胞的生长导钾通道和Cav3.2电压依赖性钙通道参与前列腺癌细胞的生长
4. ATP-sensitive potassium channel involved in modulation of nitride oxide decreasing contractility of lymphatics isolated from hemorrhagic shock rats [C] . Zhang Li-min, NIU Chun-yu*, ZHAO Zi-gang, Asian Congress for Microcirculation . 2011

机译：ATP敏感性钾通道参与调节氮化物氧化物氧化物的淋巴虫患者淋巴管的收缩性降低
5. Molecular and functional targets of methionine oxidation in large-conductance calcium-activated potassium channels. [D] . Santarelli, Lindsey Ciali. 2005

机译：大电导钙激活钾通道中蛋氨酸氧化的分子和功能靶标。
6. Modulation of potassium channel function by methionine oxidation and reduction [O] . Matthew A. Ciorba, Stefan H. Heinemann, Herbert Weissbach, 1997

机译：通过蛋氨酸氧化还原还原钾通道功能
7. Functional consequences of methionine oxidation of hERG potassium channels [O] . Zhi Su, James Limberis, Ruth L. Martin, 2007

机译：HERG钾通道甲硫氨酸氧化的功能后果

Modulation of potassium channel function by methionine oxidation and reduction

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