Phylogeny of mRNA capping enzymes

Shuang Ping Wang; Liang Deng; C. Kiong Ho

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Phylogeny of mRNA capping enzymes

机译：mRNA封端酶的系统发育

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The m~7GpppN cap structure of eukaryotic mRNA is formed cotranscriptionally by the sequential action of three enzymes: RNA triphosphatase, RNA guanylyltrans- ferase, and RNA (guanine-7)-methyltransferase. A multifunc- tional polypeptide containing all three active sites is encoded by vaccinia virus. In contrast, fungi and Chlorella virus encode monofunctional guanylyltransferase polypeptides that lack triphosphatase and methyltransferase activities. Transguany- lylation is a two-stage reaction involving a covalent enzyme- GMP intermediate. The active site is composed of six protein motifs that are conserved in order and spacing among yeast and DNA virus capping enzymes.

机译：真核mRNA的m〜7GpppN帽结构是通过三种酶（RNA三磷酸酶，RNA鸟嘌呤基转移酶和RNA（鸟嘌呤-7）-甲基转移酶）的顺序作用共转录形成的。包含所有三个活性位点的多功能多肽由痘苗病毒编码。相反，真菌和小球藻病毒编码缺乏三磷酸酶和甲基转移酶活性的单功能鸟苷基转移酶多肽。转鸟苷酸化是一个涉及共价酶-GMP中间体的两阶段反应。活性位点由六个蛋白质基序组成，这些基序在酵母和DNA病毒加帽酶之间按顺序和间隔保守。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第18期|p.9573-9578|共6页
作者
Shuang Ping Wang; Liang Deng; C. Kiong Ho;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：消除由mRNA衰减产生的帽结构涉及新的清除剂mRNA脱盖酶Aph1 / FHIT和DcpS
2. Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS [J] . Bertrand Séraphin, Valerio Taverniti Nucleic acids research . 2015,第1期

机译：消除由mRNA衰减产生的帽结构涉及新的清除剂mRNA脱盖酶Aph1 / FHIT和DcpS
3. Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme. [J] . Schwer B, Mao X, Shuman S Nucleic Acids Research . 1998,第9期

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5. Functional characterization of trypanosoma mRNA capping enzymes and archaeal RNA ligase [D] . Takagi, Yuko 2011

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6. Phylogeny of mRNA capping enzymes [O] . Shuang Ping Wang, Liang Deng, C. Kiong Ho, 1997

机译：mRNA封端酶的系统发育
7. Isolation and characterization of the Candida albicans gene for mRNA 5′-triphosphatase: association of mRNA 5′-triphosphatase and mRNA 5′-guanylyltransferase activities is essential for the function of mRNA 5′-capping enzyme in vivo1The GenBank/EMBL/DDBJ accession number for the nucleotide sequence of CaCET1 is AB016242.1 [O] . Yamada-Okabe Toshiko, Mio Toshiyuki, Matsui Mitsuaki, 1998

机译：mRNA 5'-三磷酸酶的白色念珠菌基因的分离和表征：mRNA 5'-三磷酸酶和mRNA 5'-鸟嘌呤基转移酶活性的关联对于mRNA 5'-封端酶在体内的功能至关重要1 GenBank / EMBL / DDBJ登录号CaCET1的核苷酸序列是AB016242.1

Phylogeny of mRNA capping enzymes

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