Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8~+ cytotoxic T lymphocyte responses

Christine M. Posavad; David M. Koelle; Mary F. Shaughnessy

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Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8~+ cytotoxic T lymphocyte responses

机译：感染了单纯疱疹病毒特异性CD8〜+细胞毒性T淋巴细胞反应受损的HIV感染者的严重生殖器疱疹感染

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The specific mechanisms underlying the var- ied susceptibility of HIV-infected (HIV+) individuals to op- portunistic infections (OI) are still incompletely understood. One hypothesis is that quantitative differences in specific T cell responses to a colonizing organism determine the devel- opment of an AIDS-defining OI. We evaluated this hypothesis for herpes simplex virus (HSV) infection, a common OI in HIV+ patients. Using limiting dilution analyses, the fre- quency of HSV-specific CD8~+ cytotoxic T lymphocyte precur- sors (pCTL) and proliferative precursors were quantitated in peripheral blood mononuclear cells from 20 patients coin- fected with HIV and HSV-2.

机译：HIV感染者（HIV +）对机会感染（OI）易感性不同的具体机制仍未完全了解。一种假设是，特定的T细胞对殖民生物的反应的数量差异决定了定义AIDS的OI的发展。我们评估了单纯疱疹病毒（HSV）感染这一假设，这是HIV +患者常见的OI。使用有限稀释分析，在20名感染了HIV和HSV-2的患者的外周血单个核细胞中定量了HSV特异性CD8〜+细胞毒性T淋巴细胞前体（pCTL）和增殖前体的频率。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第19期|p.10289-10294|共6页
作者
Christine M. Posavad; David M. Koelle; Mary F. Shaughnessy;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Blockade of Lymphocyte activation gene-3 (LAG-3) Pathway Improved the Size and Protective Function of Herpes Simplex Virus-Specific CD8(+) T cells against Ocular Herpes Infection and Disease [J] . Nesburn Anthony B., Srivastava Ruchi, Soumyabrata Roy, Investigative ophthalmology & visual science . 2018,第9期

机译：障碍淋巴细胞活化基因-3（LAG-3）途径改善了疱疹病毒特异性CD8（+）T细胞对眼疱感染和疾病的疱疹病毒特异性CD8（+）T细胞的尺寸和保护功能
2. Blockade of Lymphocyte activation gene-3 (LAG-3) Pathway Improved the Size and Protective Function of Herpes Simplex Virus-Specific CD8(+) T cells against Ocular Herpes Infection and Disease [J] . Nesburn Anthony B., Srivastava Ruchi, Soumyabrata Roy, Investigative ophthalmology & visual science . 2018,第9期

机译：障碍淋巴细胞活化基因-3（LAG-3）途径改善了疱疹病毒特异性CD8（+）T细胞对眼疱感染和疾病的疱疹病毒特异性CD8（+）T细胞的尺寸和保护功能
3. Differential effects of stress-induced adrenal function on components of the herpes simplex virus-specific memory cytotoxic T-lymphocyte response. [J] . Bonneau RH cmic.hmc.psu.edu, Zimmerman KM, Ikeda SC, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1998,第2期

机译：应激诱导的肾上腺功能对单纯疱疹病毒特异性记忆细胞毒性T淋巴细胞反应成分的不同影响。
4. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and "area pudenda" with low-power He-Ne laser or Acyclovir administered orally [C] . Mariano Velez-Gonzalez, Hospital del Mar, Barcelona, Effects of Low-Power Light on Biological Systems . 1996

机译：口服低功率He-Ne激光或阿昔洛韦治疗阴唇和面部单纯疱疹复发，生殖器和单纯性疱疹复发
5. A critical role and a critical period for herpes simplex virus-specific CD8+ T lymphocyte infiltration into the central nervous system: Impact on the development of stress-induced herpes simplex encephalitis. [D] . Anglen, Crystal S. 2003

机译：单纯疱疹病毒特异性CD8 + T淋巴细胞浸入中枢神经系统的关键作用和关键时期：对应激诱导的单纯疱疹性脑炎发展的影响。
6. Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses [O] . Christine M. Posavad, David M. Koelle, Mary F. Shaughnessy, 1997

机译：单纯疱疹病毒特异性CD8 +细胞毒性T淋巴细胞受损的HIV感染者中的严重生殖器疱疹感染
7. Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens [O] . M A Tigges, D Koelle, K Hartog, 1992

机译：人体CD8 +疱疹单纯疱疹病毒特异性细胞毒性T淋巴细胞克隆识别不同的病毒素蛋白抗原

Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8~+ cytotoxic T lymphocyte responses

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