RGS proteins reconstitute the rapid gating kinetics of Gβγ -activated inwardly rectifying K~+ channels

Craig A. Doupnik; Norman Davidson; Henry A. Lester

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RGS proteins reconstitute the rapid gating kinetics of Gβγ -activated inwardly rectifying K~+ channels

机译：RGS蛋白重建了Gβγ激活的内向整流K〜+通道的快速门控动力学

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G protein-gated inward rectifier K+ (GIRK) channels mediate hyperpolarizing postsynaptic potentials in the nervous system and in the heart during activation of Gα (i/o)-coupled receptors. In neurons and cardiac atrial cells the time course for receptor-mediated GIRK current deacti- vation is 20-40 times faster than that observed in heterolo- gous systems expressing cloned receptors and GIRK channels, suggesting that an additional component(s) is required to confer the rapid kinetic properties of the native transduction pathway.

机译：G蛋白门控的内向整流器K +（GIRK）通道在激活Gα（i / o）偶联受体的过程中介导神经系统和心脏的超极化突触后电位。在神经元和心脏心房细胞中，受体介导的GIRK电流失活的时间过程比在表达克隆的受体和GIRK通道的异基因系统中观察到的快20-40倍，这表明需要额外的成分赋予天然转导途径快速的动力学特性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第19期|p.10461-10466|共6页
作者
Craig A. Doupnik; Norman Davidson; Henry A. Lester;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Synergistic Activation of G Protein–Gated Inwardly Rectifying Potassium Channels by the βγ Subunits of G Proteins and Na+ and Mg2+ Ions [J] . Jér?me Petit-Jacques, Jin Liang Sui, Diomedes E. Logothetis The Journal of general physiology . 1999,第5期

机译：通过G蛋白和Na +和Mg2 +离子的βγ亚基对G蛋白腺化的对外整流钾通道的协同活化
2. Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons [J] . Constantin Stephanie, Wray Susan Endocrinology . 2016,第8期

机译：甘丙肽激活G蛋白门控向内纠正钾通道，并抑制GnRH神经元的Kisspeptin-10激活。
3. The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel [J] . Joanne Louise Leaney, Andrew Tinker Proceedings of the National Academy of Sciences of the United States of America . 2000,第10期

机译：百日咳毒素敏感的G蛋白家族成员在受体偶联至G蛋白门控的内向整流钾通道的激活中的作用
4. FLOW SENSITIVITY OF INWARDLY-RECTIFYING K{sup}+ CHANNELS IN HUMAN AOTIC ENDOTHELIUM [C] . Yun Fang, Victor Romanenko, Peter F. Davies, IASTED International Conference on Biomechanics . 2005

机译：在人体美食内皮中向内整流k {sup} +通道的流动敏感性
5. Development of Molecular Tools for the Investigation of G protein-gated Inwardly Rectifying Potassium (GIRK) Channels. [D] . Ramos-Hunter, Susan Joanne. 2017

机译：用于研究G蛋白门控的内向整流钾（GIRK）通道的分子工具的开发。
6. RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K+ channels [O] . Craig A. Doupnik, Norman Davidson, Henry A. Lester, 1997

机译：RGS蛋白重建了Gβγ激活的内向整流K +通道的快速门控动力学
7. RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K^+ channels [O] . Doupnik Craig A., Davidson Norman, Lester Henry A., 1997

机译：RGS蛋白重构了Gβγ激活的内向整流K ^ +通道的快速门控动力学
8. Role of Mg(2+) in the Inactivation of Inwardly Rectifying K(+) Channels in AorticEndothelial Cells [R] . Elam, T. R., Lansman, J. B. 1995

机译：mg（2+）在主动脉内皮细胞内向整流K（+）通道失活中的作用

RGS proteins reconstitute the rapid gating kinetics of Gβγ -activated inwardly rectifying K~+ channels

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