Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat

Ning Quan; Michael Whiteside; Leopold Kim

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Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat

机译：外周脂多糖给药后在中枢神经系统中诱导抑制因子κBαmRNA的表达：大鼠原位杂交组织化学研究

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In this study we investigate the mRNA ex- pression of inhibitory factor κBα(IκBα) in cells of the rat brain induced by an intraperitoneal (i.p.) injection of lipo- polysaccharide (LPS). IκB controls the activity of nuclear factor κB, which regulates the transcription of many immune signal molecules. The detection of IκB induction, therefore, would reveal the extent and the cellular location of brain- derived immune molecules in response to peripheral immune challenges. Low levels of IκBα mRNA were found in the large blood vessels and in circumventricular organs (CVOs) of saline-injected control animals. After an i.p. LPS injection (2.5 mg/kg), dramatic induction of IκBα mRNA occurred in four spatio-temporal patterns.

机译：在这项研究中，我们研究了腹膜内（ip。）注射脂多糖（LPS）诱导的大鼠脑细胞中抑制因子κBα（IκBα）的mRNA表达。 IκB控制着核因子κB的活性，后者调节许多免疫信号分子的转录。因此，IκB诱导的检测将揭示响应于外周免疫挑战的脑源性免疫分子的范围和细胞位置。在注射盐水的对照动物的大血管和室间隔器官（CVO）中发现了低水平的IκBαmRNA。在IP后LPS注射（2.5 mg / kg），IκBαmRNA的显着诱导以四种时空模式发生。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第20期|p.10985-10990|共6页
作者
Ning Quan; Michael Whiteside; Leopold Kim;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat [O] . Ning Quan, Michael Whiteside, Leopold Kim, 1997

机译：外周脂多糖给药后在中枢神经系统中诱导抑制因子κBαmRNA的诱导：大鼠原位杂交组织化学研究
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Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat

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