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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome P450s: Evidence for involvement in host-plant allelochemical resistance
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Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome P450s: Evidence for involvement in host-plant allelochemical resistance

机译：异种诱导型果蝇细胞色素P450家族的分子克隆：参与宿主植物化感抗性的证据

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摘要

Cytochrome P450s constitute a superfamily of genes encoding mostly microsomal hemoproteins that play a dominant role in the metabolism of a wide variety of both endogenous and foreign compounds. In insects, xenobiotic metabolism (i.e., metabolism of insecticides and toxic natural plant compounds) is known to involve members of the CYP6 family of cytochrome P450s. Use of a 3' RACE (rapid ampli- fication of cDNA ends) strategy with a degenerate primer based on the conserved cytochrome P450 heme-binding de- capeptide loop resulted in the amplification of four cDNA sequences representing another family of cytochrome P450 genes (CYP28) from two species of isoquinoline alkaloid- resistant Drosophila and the cosmopolitan species Drosophila hydei.
机译：细胞色素P450构成基因的超家族，其主要编码微粒体血蛋白，这些蛋白在多种内源性和外源性化合物的代谢中起主要作用。在昆虫中，已知异种生物代谢（即杀虫剂和有毒天然植物化合物的代谢）涉及细胞色素P450 CYP6家族的成员。基于保守的细胞色素P450血红素结合十肽环的简并引物使用3'RACE（cDNA末端快速扩增）策略，导致代表另一个细胞色素P450基因家族的四个cDNA序列被扩增（CYP28 ）来自两种耐异喹啉类生物碱的果蝇和世界性果蝇（Drosophila hydei）。

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