Minisatellite instability in severe combined immunodeficiency mouse cells

Hiroshi Imai; Hitoshi Nakagama; Kenshi Komatsu

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Minisatellite instability in severe combined immunodeficiency mouse cells

【24h】

Minisatellite instability in severe combined immunodeficiency mouse cells

机译：严重的联合免疫缺陷小鼠细胞中的小卫星不稳定性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We have recently found that okadaic acid, which shows strong inhibitory activity on protein serine/threonine phosphatases and tumor-promoting activity in vivo and in vitro, induces minisatellite mutation (MSM). Human tumors and chemically induced counterparts in ex- perimental animals are also sometimes associated with MSM. In the present study, we demonstrated minisatellite (MS) instability in severe combined immunodeficiency (SCID) cells in which the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is impaired.

机译：我们最近发现，冈田酸可诱导微卫星突变（MSM），冈田酸对蛋白质丝氨酸/苏氨酸磷酸酶具有很强的抑制活性，并且在体内外均具有促进肿瘤的活性。实验动物中的人类肿瘤和化学诱导的对应物有时也与MSM有关。在本研究中，我们证明了严重的联合免疫缺陷（SCID）细胞中的微卫星（MS）不稳定性，其中DNA依赖性蛋白激酶催化亚基（DNA-PKcs）受损。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第20期|p.10817-10820|共4页
作者
Hiroshi Imai; Hitoshi Nakagama; Kenshi Komatsu;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency [J] . Andrea Z. Tuckett, Raymond H. Thornton, Richard J. O’Reilly, Journal of Hematology and Oncology . 2017,第1期

机译：脑内注射造血祖细胞在严重组合免疫缺陷的小鼠模型中建立功能性T细胞发育
2. Evaluation of different protocols for gene transfer into non-obese diabetes/severe combined immunodeficiency disease mouse repopulating cells. [J] . Ebeling P, Bach P, Sorg U, Journal of Cancer Research and Clinical Oncology . 2007,第3期

机译：评价将基因转移到非肥胖型糖尿病/重症合并免疫缺陷疾病小鼠再造细胞中的不同方案。
3. Evaluation of different protocols for gene transfer into non-obese diabetes/severe combined immunodeficiency disease mouse repopulating cells [J] . Peter Ebeling, P. Bach, U. Sorg, Journal of Cancer Research and Clinical Oncology . 2007,第3期

机译：评价将基因转移到非肥胖型糖尿病/重症合并免疫缺陷病小鼠繁殖细胞中的不同方案
4. Canine X-linked severe combined immunodeficiency: a model for investigating the requirement for the common gamma chain (#gamma#c) in lymphocyte development and function [C] . Peter J. Felsburg Annual Meeting of the American Society for Veterinary Clinical Pathology . 2000

机译：犬X链接严重的综合免疫缺陷：一种研究淋巴细胞发育和功能常见γ链（＃γ＃c）的要求
5. Characterization of naturally occurring severe combined immunodeficiency (SCID) in a line of pigs and their response to porcine reproductive and respiratory syndrome virus (PRRSV) infection. [D] . Cino-Ozuna, Ada Giselle. 2016

机译：猪中自然发生的严重联合免疫缺陷症（SCID）的特征及其对猪繁殖与呼吸综合征病毒（PRRSV）感染的反应。
6. Minisatellite instability in severe combined immunodeficiency mouse cells [O] . Hiroshi Imai, Hitoshi Nakagama, Kenshi Komatsu, 1997

机译：严重的联合免疫缺陷小鼠细胞中的小卫星不稳定性
7. Minisatellite instability in severe combined immunodeficiency mouse cells [O] . H. Imai, H. Nakagama, K. Komatsu, 1997

机译：小型卫星在严重组合免疫缺陷小鼠细胞中的不稳定性

Minisatellite instability in severe combined immunodeficiency mouse cells

摘要

著录项

相似文献

相关主题

期刊订阅