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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Telomere lengthening and telomerase activation during human B cell differentiation
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Telomere lengthening and telomerase activation during human B cell differentiation

机译：人B细胞分化过程中端粒延长和端粒酶激活

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摘要

The function of the immune system is highly dependent on cellular differentiation and clonal expansion of antigen-specific lymphocytes. However, little is known about mechanisms that may have evolved to protect replicative poten- tial in actively dividing lymphocytes during immune differenti- ation and response. Here we report an analysis of telomere length and telomerase expression, factors implicated in the regulation of cellular replicative lifespan, in human B cell subsets. In contrast to previous observations, in which telomere shortening and concomitant loss of replicative potential occur in the process of somatic cell differentiation and cell division, it was found that germinal center (GC) B cells, a compartment characterized by extensive clonal expansion and selection, had significantly longer telomeric restriction fragments than those of precursor naive B cells.
机译：免疫系统的功能高度依赖于抗原特异性淋巴细胞的细胞分化和克隆扩增。但是，对于在免疫分化和应答过程中保护主动分裂的淋巴细胞中的复制潜能的机制可能知之甚少。在这里，我们报告了人类B细胞亚群中端粒长度和端粒酶表达的分析，端粒酶表达与细胞复制寿命调控有关。与先前的观察结果相反，端粒缩短和伴随的复制潜能的丧失发生在体细胞分化和细胞分裂的过程中，发现生发中心（GC）B细胞是一个以广泛的克隆扩增和选择为特征的区室，具有比原始幼稚B细胞更长的端粒限制性片段。

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