Induction of minisatellite mutation in NIH 3T3 cells by treatment with the tumor promoter okadaic acid

Hitoshi Nakagama; Shigeto Kaneko; Hiroshi Shima

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Induction of minisatellite mutation in NIH 3T3 cells by treatment with the tumor promoter okadaic acid

机译：肿瘤启动子冈田酸处理诱导NIH 3T3细胞中小卫星突变

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Okadaic acid (OA) is a strong tumor pro- moter of mouse skin carcinogenesis and also a potent inhibitor of serine/threonine protein phosphatases. OA induces vari- ous genetic alterations in cultured cells, such as diphtheria- toxin-resistance mutations, sister chromatid exchange, exclu- sion of exogenous transforming oncogenes, and gene ampli- fication. The present study revealed that it caused minisatellite mutation (MSM) at a high frequency in NIH 3T3 cells, although no microsatellite mutation was found. Nine of 31 clones (29/100) exhibited MSM after 6 days of OA treatment, as opposed to only 1 of 30 clones (3/100) without OA exposure.

机译：冈田酸（OA）是小鼠皮肤癌变的强大肿瘤促进剂，也是丝氨酸/苏氨酸蛋白磷酸酶的有效抑制剂。 OA诱导培养细胞的各种遗传改变，例如白喉抗药性突变，姐妹染色单体交换，外源转化癌基因的排他性和基因扩增。本研究表明，尽管未发现微卫星突变，但它在NIH 3T3细胞中引起高频率的微卫星突变（MSM）。 OA处理6天后，有31个克隆（29/100）中有9个表现出MSM，而没有OA暴露的30个克隆（3/100）中只有1个。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第20期|p.10813-10816|共4页
作者
Hitoshi Nakagama; Shigeto Kaneko; Hiroshi Shima;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Induction of Ornithine Decarboxylase Activity in Mouse Skin by a Possible Tumor Promoter, Okadaic Acid [J] . Hirota FUJIKI, Masami SUGANUMA, Hiroko SUGURI, Proceedings of the Japan Academy, Series B. Physical and Biological Sciences . 2006,第2期

机译：可能的肿瘤启动子冈田酸诱导小鼠皮肤中鸟氨酸脱羧酶活性
2. Suppressive effects of chlorophyllin on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promoter-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells. [J] . Okai Y, Higashi Okai K, Yano Y, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1996,第1期

机译：叶绿素对鼠伤寒沙门氏菌（TA 1535 / pSK 1002）中诱变剂诱导的umu C基因表达的抑制作用以及BALB / c 3T3成纤维细胞中依赖肿瘤启动子的鸟氨酸脱羧酶的诱导作用。
3. Different sensitivities of p42 mitogen-activated protein kinase to phorbol ester and okadaic acid tumor promoters among cell types. [J] . Rossini GP, Pinna C, Malaguti C Biochemical Pharmacology . 1999,第2期

机译：在细胞类型中，p42丝裂原活化蛋白激酶对佛波酯和冈田酸肿瘤启动子的敏感性不同。
4. Comparison of WI-38 and NIH/3T3 Cells As Standards for the Evaluation of the Inhibition of Pancreatic Cancer Cell Lines by Organotin Polymers Derived From Drugs Without Aromaticity-Thiodiglycolic Acid, Chelidonic Acid, and Isomannide [C] . Michael R. Roner, Charles E. Carraher Jr., Alisa Moric Louisiana Meeting . 2013

机译：WI-38和NIH / 3T3细胞作为评估胰腺癌细胞系评价的标准，其通过无芳香性 - 硫代脒酸，Chelidonic酸和Isomannide衍生的有机锡聚合物评估胰腺癌细胞系的抑制
5. Biocompatibility of electrospun polymer nanofibers (EPNs) with NIH 3T3 cell line and interaction of quercetin with different flavonoids: Induction of phase II enzymes in vitro cancer cell lines [D] . Benavides, Brenda S. 2011

机译：电纺聚合物纳米纤维（EPN）与NIH 3T3细胞系的生物相容性以及槲皮素与不同类黄酮的相互作用：体外癌细胞系中II期酶的诱导
6. Induction of minisatellite mutation in NIH 3T3 cells by treatment with the tumor promoter okadaic acid [O] . Hitoshi Nakagama, Shigeto Kaneko, Hiroshi Shima, 1997

机译：肿瘤启动子冈田酸处理诱导NIH 3T3细胞微卫星突变
7. Physiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells [O] . 1991

机译：NIH 3T3细胞中病灶形成和致瘤性的生理诱导和逆转
8. Differentiation, early response gene expression, and apoptosis induction in human breast tumor cells by Okadaic Acid and related inhibitors of protein phosphatases 1 and 2A. Okadaic acid effects on human breast tumor cells [R] . Kiguchi, K. , Giometti, C. , Chubb, C. H. , 1992

机译：冈田酸和蛋白磷酸酶1和2a的相关抑制剂在人乳腺肿瘤细胞中的分化，早期反应基因表达和凋亡诱导。冈田酸对人乳腺癌细胞的影响

Induction of minisatellite mutation in NIH 3T3 cells by treatment with the tumor promoter okadaic acid

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