Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth

Wataru Araki; Richard J. Wurtman

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Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth

机译：通过神经突向外生长的神经元细胞中的二酰基甘油水平控制膜磷脂酰胆碱的生物合成

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Phospholipids are the major components of cell membranes and are required for cellular growth. We studied membrane phosphatidylcholine (PtdCho) biosynthesis in neu- ronal cells undergoing neurite outgrowth, by using PC12 cells as a model system. When neurite outgrowth was induced by expos- ing PC12 cells to nerve growth factor for 2 and 4 days, the amounts of [~14C]choline incorporated into [~14C]phosphatidyl- choline per cell (i.e., per DNA) increased approximately 5- and 10-fold, respectively, as compared with control cells, reflecting increases in the rate of PtdCho biosynthesis. [~14C]choline uptake was not affected.

机译：磷脂是细胞膜的主要成分，是细胞生长所必需的。我们通过使用PC12细胞作为模型系统研究了发生神经突生长的神经细胞中的膜磷脂酰胆碱（PtdCho）生物合成。通过将PC12细胞暴露于神经生长因子2天和4天来诱导神经突生长，每个细胞（即每个DNA）掺入[〜14C]磷脂酰胆碱中的[〜14C]胆碱的量增加了约5-与对照细胞相比，PtdCho生物合成速率增加了10倍和10倍。 [〜14C]胆碱的摄取不受影响。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第22期|p.11946-11950|共5页
作者
Wataru Araki; Richard J. Wurtman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth [O] . Wataru Araki, Richard J. Wurtman 1997

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Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth

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