Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung

Gerald B. Pier; Martha Grout; Tanweer S. Zaidi

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Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung

机译：囊性纤维化跨膜电导调节剂是一种上皮细胞受体，可从肺中清除铜绿假单胞菌

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The cystic fibrosis transmembrane conduc- tance regulator (CFTR) is a chloride ion channel, but its relationship to the primary clinical manifestation of CF, chronic Pseudomonas aeruginosa pulmonary infection, is un- clear. We report that CFTR is a cellular receptor for binding, endocytosing, and clearing P. aeruginosa from the normal lung. Murine cells expressing recombinant human wild-type CFTR ingested 30-100 times as many P. aeruginosa as cells lacking CFTR or expressing mutant △F508 CFTR protein. Purified CFTR inhibited ingestion of P. aeruginosa by human airway epithelial cells.

机译：囊性纤维化跨膜电导率调节剂（CFTR）是氯离子通道，但与CF的主要临床表现慢性铜绿假单胞菌肺部感染之间的关系尚不清楚。我们报告说CFTR是一种细胞受体，用于从正常肺中结合，内吞和清除铜绿假单胞菌。表达重组人野生型CFTR的鼠细胞摄入的铜绿假单胞菌是缺少CFTR或表达突变型△F508 CFTR蛋白的细胞的30-100倍。纯化的CFTR抑制人气道上皮细胞摄入铜绿假单胞菌。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第22期|p.12088-12093|共6页
作者
Gerald B. Pier; Martha Grout; Tanweer S. Zaidi;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Pseudomonas aeruginosa: can studies in engineered cells tell us why is it such a problem in people with cystic fibrosis? Focus on "Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa". [J] . Zeitlin PL American Journal of Physiology . 2009,第2aPta1期

机译：铜绿假单胞菌：对工程细胞的研究能否告诉我们，为什么在囊性纤维化患者中出现这种问题？专注于“囊性纤维化跨膜电导调节剂和caveolin-1调节铜绿假单胞菌上皮细胞内在化”。
2. Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization [J] . Kong FS, Young L, Chen Y, Cellular microbiology . 2006,第7期

机译：铜绿假单胞菌绿脓素使肺上皮液泡ATPase依赖性囊性纤维化跨膜电导调节剂的表达和定位失活
3. Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells Is Required for Pseudomonas aeruginosa-Induced Cellular Activation [J] . Michael P. Kowalski, Gerald B. Pier The journal of immunology . 2004,第1期

机译：铜绿假单胞菌诱导的细胞活化需要囊性纤维化跨膜电导调节剂定位于上皮细胞的脂质筏。
4. Cystic fibrosis transmembrane conductance regulator gene mutations cause 'black' pigment gallstone formation: new insights from mouse models and implications for therapeutic interventions in cystic fibrosis [C] . A. L. BRODERICK, H. WITTENBURG, M. A. LYONS, Falk Symposium . 2004

机译：囊性纤维化跨膜电导调节剂基因突变引起'黑色'颜料胆结石形成：来自小鼠模型的新见解，以及对囊性纤维化治疗干预的影响
5. Treating an N-glycosylation abnormality in airways with a cystic fibrosis transmembrane conductance regulator protein deficiency reduces Pseudomonas aeruginosa colonization; A hallmark symptom of cystic fibrosis [D] . Martino, Ashley Thomas 2007

机译：用囊性纤维化跨膜电导调节蛋白缺乏治疗气道N-糖基化异常可减少铜绿假单胞菌定植；囊性纤维化的典型症状
6. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung [O] . Gerald B. Pier, Martha Grout, Tanweer S. Zaidi 1997

机译：囊性纤维化跨膜电导调节剂是上皮细胞受体用于清除肺中的铜绿假单胞菌
7. Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vaculoar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization [O] . Fansheng Kong, Lisa Young, Yi Chen, 2006

机译：假单胞菌铜绿假单胞菌菌灭活肺上皮假期ATP依赖性囊性纤维化跨膜电导调节剂表达和定位

Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung

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