Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Odile Devergne; Mark Birkenbach; Elliott Kieff

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Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

机译：爱泼斯坦-巴尔病毒诱导的基因3和白介素12的p35亚基形成新的异二聚体造血素

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The Epstein-Barr virus-induced gene 3 (EBI3) is a novel soluble hematopoietin component related to the p40 subunit of interleukin 12 (IL-12). When EBI3 was expressed in cells, it accumulated in the endoplasmic reticu- lum and associated with the molecular chaperone calnexin, indicating that subsequent processing and secretion might be dependent on association with a second subunit. Coimmuno- precipitations from lysates and culture media of cells trans- fected with expression vectors for EBI3 and/or the p35 subunit of IL-12 now reveal a specific association of EBI3 with p35. Coexpression of EBI3 and p35 mutually facilitates their secretion.

机译：爱泼斯坦-巴尔病毒诱导的基因3（EBI3）是与白介素12（IL-12）p40亚基相关的新型可溶性造血素成分。当EBI3在细胞中表达时，它在内质网中积累并与分子伴侣钙合蛋白有关，这表明随后的加工和分泌可能取决于与第二个亚基的结合。现在，用EBI3和/或IL-12的p35亚基表达载体转染的细胞的裂解液和培养基中的共免疫沉淀表明EBI3与p35有特定的联系。 EBI3和p35的共表达相互促进其分泌。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第22期|p.12041-12046|共6页
作者
Odile Devergne; Mark Birkenbach; Elliott Kieff;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Rare polymorphisms in the promoter regions of the human interleukin-12 p35 and interleukin-12 p40 subunit genes. [J] . Pravica V, Brogan IJ, Hutchinson IV European journal of immunogenetics: official journal of the British Society for Histocompatibility and Immunogenetics . 2000,第1期

机译：人白介素12 p35和白介素12 p40亚基基因启动子区域中的罕见多态性。
2. Expression of Epstein-Barr Virus-Induced Gene 3, an Interleukin-12 p40-Related Molecule, throughout Human Pregnancy : Involvement of Syncytiotrophoblasts and Extravillous Trophoblasts [J] . Odile Devergne, Aurore Coulomb-L’Herminé, Francis Capel, American Journal of Pathology . 2001,第5期

机译：爱泼斯坦-巴尔病毒诱导的基因3，白介素12 p40相关分子，在整个人类妊娠中的表达：合体滋养层细胞和绒毛外滋养层细胞的参与
3. Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits. [J] . Nascimento DS, do-Vale A, Tomas AM, Molecular Immunology . 2007,第9期

机译：响应海鲈（Dicentrarchus labrax L.）白介素12 p40和p35亚基细菌暴露的克隆，启动子分析和表达。
4. Association of porcine interleukin-12 receptor β2 (IL-12Rβ2) gene alleles with the development of high or low interferon-γ response to PRRS virus [C] . Federico A. Zuckermann, William Schnitzlein, Robert Husmann, Annual Meeting of the American Association of Swine Veterinarians . 2004

机译：猪白细胞介素-12-12受体β2（IL-12Rβ2）基因等位基因与PRRS病毒的高或低干扰素-γγ的基因等位基因
5. The role of interleukin-12 in the pathogenesis of Sendai virus-induced airway disease. [D] . Stone, Amy Elizabeth Seymour. 2002

机译：白介素12在仙台病毒诱发的气道疾病发病机理中的作用。
6. Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin [O] . Odile Devergne, Mark Birkenbach, Elliott Kieff 1997

机译：爱泼斯坦-巴尔病毒诱导的基因3和白介素12的p35亚基形成新的异源二聚体造血素
7. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin [O] . O. Devergne, M. Birkenbach, E. Kieff 1997

机译：Epstein-BARR病毒诱导的基因3和白细胞介素12的P35亚基形成新的异二聚体胰岛素

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

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