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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
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Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer

机译：通过腺病毒介导的基因转移恢复衰竭心室心肌细胞中的β-肾上腺素信号传导

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摘要

Cardiovascular gene therapy is a novel ap- proach to the treatment of diseases such as congestive heart failure (CHF). Gene transfer to the heart would allow for the replacement of defective or missing cellular proteins that may improve cardiac performance. Our laboratory has been fo- cusing on the feasibility of restoring β-adrenergic signaling deficiencies that are a characteristic of chronic CHF. We have now studied isolated ventricular myocytes from rabbits that have been chronically paced to produce hemodynamic failure. We document molecular β-adrenergic signaling defects in- cluding down-regulation of myocardial β-adrenergic recep- tors (β-ARs), functional β-AR uncoupling, and an up- regulation of the β-AR kinase (βARK1).
机译：心血管基因治疗是一种治疗充血性心力衰竭（CHF）等疾病的新颖方法。基因转移到心脏会允许替换有缺陷或缺失的细胞蛋白，从而改善心脏功能。我们的实验室一直在研究恢复慢性CHF的特征性β-肾上腺素能信号缺陷的可行性。现在，我们已经研究了从兔子中分离出来的心室肌细胞，这些细胞经过长期的步调产生血流动力学衰竭。我们记录了分子β-肾上腺素信号传导缺陷，包括心肌β-肾上腺素受体（β-ARs）的下调，功能性β-AR的解偶联以及β-AR激酶（βARK1）的上调。

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