Twist and shout (and pull): Molecular chiropractors undo DNA

John F.Marko

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Twist and shout (and pull): Molecular chiropractors undo DNA

机译：扭曲和喊叫（和拉扯）：分子按摩师撤消DNA

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The study of helicases on the Y-shaped templates is one of a number of interesting enzymoilogical micromanipulation studies that now can be considered. It will not be long before DNA replication, recombination, topology change, tran- scription regulation, and chromatin assembly are studied using micromanipulation. Similar methods can be applied to other large biomolecules as evidenced by recent experiments studying denaturation of the protein titine by applied force (26-28); one can imagine using the technique of Essevaz-Rou- let et al. (4) to study helix-loop structure of large RNAs (3). Revealing a unique combination of structural and energetic information, this molecular chiropracty is a sharp tool for ultrastructural study of the biochemical transactions of life.

机译：Y型模板上解旋酶的研究是许多现在可以考虑的有趣的酶学微操作研究之一。使用显微操作研究DNA复制，重组，拓扑结构变化，转录调控和染色质组装将很快。类似的方法也可以应用于其他大生物分子，最近的研究证明了施加力使蛋白质的泰坦变性（26-28）。可以想象使用Essevaz-Roulet等人的技术。（4）研究大RNA的螺旋环结构（3）。该分子按摩疗法揭示了结构信息和能量信息的独特组合，是进行生命生物化学交易的超结构研究的有效工具。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第22期|p.11770-11772|共3页
作者
John F.Marko;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Inclusion of push-pull N-methylpyridinium salts within surfactant hydrogels: is their excited state intramolecular charge transfer mediated by twisting? [J] . Cesaretti A., Carlotti B., Germani R., Physical chemistry chemical physics: PCCP . 2015,第26期

机译：在表面活性剂水凝胶中包括推挽式N-甲基吡啶鎓盐：它们的激发态是通过扭曲介导的分子内电荷转移吗？
2. B-DNA under stress: over- and untwisting of DNA during molecular dynamics simulations. [J] . Kannan S, Kohlhoff K, Zacharias M Biophysical Journal . 2006,第8期

机译：应力下的B-DNA：分子动力学模拟过程中DNA的过度扭曲和扭曲。
3. DNA sliding in nucleosomes via twist defect propagation revealed by molecular simulations [J] . Brandani Giovanni B., Niina Toru, Tan Cheng, Nucleic Acids Research . 2018,第6期

机译：通过分子模拟显示的扭曲缺陷繁殖，DNA在核体中滑动
4. Twisting Motion Dependent Charge Transport Properties Of Poly(dG)-Poly(dC) DNA Molecular Wire [C] . E. Yudiarsah, D. K. Suhendro, R. Saleh International Conference on Theoretical and Applied Physics . 2014

机译：聚（DG）-Poly（DC）DNA分子线的扭转运动依赖性电荷特性
5. Single molecule studies of DNA twisting and the mechanism of type II topoisomerases. [D] . Stone, Michael David. 2003

机译：DNA扭曲的单分子研究和II型拓扑异构酶的机制。
6. Twist and shout (and pull): Molecular chiropractors undo DNA [O] . John F. Marko 1997

机译：扭曲和大喊（和拉扯）：分子脊医undo DNA
7. B-DNA Under Stress: Over- and Untwisting of DNA during Molecular Dynamics Simulations [O] . Kannan, Srinivasaraghavan, Kohlhoff, Kai, Zacharias, Martin 2006

机译：应力下的B-DNA：分子动力学模拟过程中DNA的过度扭曲和扭曲

Twist and shout (and pull): Molecular chiropractors undo DNA

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