Evaluating treatment protocols to prevent antibiotic resistance

Sebastian Bonhoeffer; Marc Lipsitch; Bruce R. Levin

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Evaluating treatment protocols to prevent antibiotic resistance

机译：评估治疗方案以预防抗生素耐药性

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The spread of bacteria resistant to antimi- crobial agents calls for population-wide treatment strategies to delay or reverse the trend toward antibiotic resistance. Here we propose new criteria for the evaluation of the population- wide effects of treatment protocols for directly transmitted bacterial infections and discuss different usage patterns for single and multiple antibiotic therapy. A mathematical model suggests that the long-term benefit of single drug treatment from introduction of the antibiotic until a high frequency of resistance precludes its use is almost independent of the pattern of antibiotic use.

机译：对抗菌剂产生抗药性的细菌的传播要求在全人群范围内采取治疗策略，以延缓或逆转抗生素耐药性的趋势。在这里，我们提出了用于评估直接传播细菌感染的治疗方案对整个人群的影响的新标准，并讨论了单一和多种抗生素治疗的不同使用模式。一个数学模型表明，从引入抗生素到耐药性的高频率阻止单药治疗的长期获益几乎与抗生素的使用方式无关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第22期|p.12106-12111|共6页
作者
Sebastian Bonhoeffer; Marc Lipsitch; Bruce R. Levin;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Qualitative analysis of models with different treatment protocols to prevent antibiotic resistance [J] . Sun H.-R., Lu X., Ruan S. Mathematical Biosciences: An International Journal . 2010,第1期

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4. Colloidal metal oxide nanoparticle systems: the new promising way to prevent antibiotic resistance during treatment of local infectious processes [C] . Y Karasenkov, G Frolov, I Pogorelsky International Youth Confernece on Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology . 2016

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5. Occurrence and proliferation of antibiotics and antibiotic resistance in wastewater treatment plants. [D] . Neyestani, Majid. 2016

机译：废水处理厂中抗生素的发生和扩散以及抗生素耐药性。
6. Evaluating treatment protocols to prevent antibiotic resistance [O] . Sebastian Bonhoeffer, Marc Lipsitch, Bruce R. Levin 1997

机译：评估治疗方案以预防抗生素耐药
7. Qualitative analysis of models with different treatment protocols to prevent antibiotic resistance [O] . Hong-Rui Sun, Xinxin Lu, Shigui Ruan 2010

机译：不同治疗方案模型的定性分析，防止抗生素抗性

Evaluating treatment protocols to prevent antibiotic resistance

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