Human deoxycytidine kinase is located in the cell nucleus

Magnus Johansson; Sophia Brismar; Anna Karlsson

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Human deoxycytidine kinase is located in the cell nucleus

机译：人类脱氧胞苷激酶位于细胞核中

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Human deoxyribonucleoside kinases are re- quired for the pharmacological activity of several clinically important anticancer and antiviral nucleoside analogs. Hu- man deoxycytidine kinase and thymidine kinase 1 are de- scribed as cytosolic enzymes in the literature, whereas human deoxyguanosine kinase and thymidine kinase 2 are believed to be located in the mitochondria. We expressed the four human deoxyribonucleoside kinases as fusion proteins with the green fluorescent protein to study their intracellular locations in vivo. Our data showed that the human deoxycytidine kinase is located in the cell nucleus and the human deoxyguanosine kinase is located in the mitochondria.

机译：人类脱氧核糖核苷激酶需要几种临床上重要的抗癌和抗病毒核苷类似物的药理活性。在文献中人类脱氧胞苷激酶和胸苷激酶1被描述为胞质酶，而人类脱氧鸟苷激酶和胸苷激酶2被认为位于线粒体中。我们将四种人脱氧核糖核苷激酶表达为与绿色荧光蛋白融合的蛋白，以研究它们在体内的细胞内位置。我们的数据表明，人脱氧胞苷激酶位于细胞核中，而人脱氧鸟苷激酶位于线粒体中。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第22期|p.11941-11945|共5页
作者
Magnus Johansson; Sophia Brismar; Anna Karlsson;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Metabolism in human cells of the D and L enantiomers of the carbocyclic analog of 2'-deoxyguanosine: substrate activity with deoxycytidine kinase, mitochondrial deoxyguanosine kinase, and 5'-nucleotidase. [J] . Bennett LL Jr, Allan PW, Arnett G, Antimicrobial agents and chemotherapy. . 1998,第5期

机译：2'-脱氧鸟苷碳环类似物的D和L对映体在人细胞中的代谢：具有脱氧胞苷激酶，线粒体脱氧鸟苷激酶和5'-核苷酸酶的底物活性。
2. RNAi depletion of deoxycytidine and deoxyguanosine kinase in human leukemic CEM cells. [J] . Fyrberg A, Albertioni F, Lotfi K Nucleosides, nucleotides and nucleic acids . 2008,第6a7期

机译：人白血病CEM细胞中脱氧胞苷和脱氧鸟苷激酶的RNAi消耗。
3. Identification of phosphorylation sites on human deoxycytidine kinase after overexpression in eucaryotic cells. [J] . Smal C, Vertommen D, Bertrand L, Nucleosides, nucleotides and nucleic acids . 2006,第9a11期

机译：在真核细胞中过表达后，鉴定人脱氧胞苷激酶上的磷酸化位点。
4. Extracellular matrix proteins mediate osteogenic differentiation of human mesenchymal stem cells on phosphate functionalized gels through integrin mediated focal adhesion kinase signaling [C] . Navakanth Gandavarapu, Kristi S. Anseth Annual meeting of the Society for Biomaterials . 2011

机译：细胞外基质蛋白通过整合素介导的粘着斑激酶信号传导介导人间充质干细胞在磷酸盐功能化凝胶上的成骨分化
5. The effect of inorganic lead on DNA synthesis in 1321N1 human astrocytoma cells: Roles of protein kinase C and mitogen-activated protein kinases. [D] . Lu, Hailing. 2001

机译：无机铅对1321N1人星形细胞瘤细胞DNA合成的影响：蛋白激酶C和促分裂原活化蛋白激酶的作用。
6. Human deoxycytidine kinase is located in the cell nucleus [O] . Magnus Johansson, Sophia Brismar, Anna Karlsson 1997

机译：人类脱氧胞苷激酶位于细胞核中
7. Transfection of the Human Deoxycytidine Kinase cDNA Enhances the Cytotoxic Effects of Cytosine Arabinoside on Human Neuroblastoma Cells 601 [O] . Chin-To Fong, Stephen J Pollock, Joseph F Sanchez 1997

机译：转染人脱氧胞苷激酶cDNA增强了胞嘧啶阿拉伯苷对人神经母细胞瘤细胞601的细胞毒性作用

Human deoxycytidine kinase is located in the cell nucleus

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