Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells

Toru Kondo; Takakazu Yokokura; Shigekazu Nagata

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Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells

机译：Fas和收割者在果蝇细胞中激活独特的半胱天冬酶样蛋白酶

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摘要

The cytoplasmic region of Fas, a mammalian death factor receptor, shares a limited homology with reaper, an apoptosis-inducing protein in Drosophila. Expression of either the Fas cytoplasmic region (FasC) or of reaper in Drosophila cells caused cell death. The death process induced by FasC or reaper was inhibited by crmA or p35, suggesting that its death process is mediated by caspase-like proteases. Both Ac-YVAD aldehyde and Ac-DEVD aldehyde, specific inhibitors of caspase 1- and caspase 3-like proteases, respec- tively, inhibited the FasC-induced death of Drosophila cells. However, the cell death induced by reaper was inhibited by Ac-DEVD aldehyde, but not by Ac-YVAD aldehyde.

机译：Fas（一种哺乳动物死亡因子受体）的胞质区与果蝇中的一种凋亡诱导蛋白reaper具有有限的同源性。果蝇细胞中Fas胞质区（FasC）或收割者的表达引起细胞死亡。 FasC或收割者诱导的死亡过程被crmA或p35抑制，这表明其死亡过程是由caspase样蛋白酶介导的。 caspase 1和caspase 3类蛋白酶的特异性抑制剂Ac-YVAD醛和Ac-DEVD醛均分别抑制FasC诱导的果蝇细胞死亡。但是，收割者诱导的细胞死亡受Ac-DEVD醛抑制，而不受Ac-YVAD醛抑制。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第22期|p.11951-11956|共6页
作者
Toru Kondo; Takakazu Yokokura; Shigekazu Nagata;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells [O] . Toru Kondo, Takakazu Yokokura, Shigekazu Nagata 1997

机译：Fas和收割者的果蝇细胞激活不同的半胱天冬酶样蛋白酶
7. Erratum: Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes [O] . JP Wing, L Zhou, LM Schwartz, 1999

机译：错误：不同细胞杀死果蝇收割机，头部缺陷和严峻基因的细胞杀伤性质

Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells

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