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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Phagocytosis of rod outer segments by retinal pigment epithelial cells requires αvβ5 integrin for binding but not for internalization
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Phagocytosis of rod outer segments by retinal pigment epithelial cells requires αvβ5 integrin for binding but not for internalization

机译：视网膜色素上皮细胞对杆外部节段的吞噬作用需要αvβ5整联蛋白来结合，而不需要内在化

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摘要

Phagocytosis of shed photoreceptor rod outer segments (ROS) by the retinal pigment epithelium (RPE) is essential for retinal function. Here, we demonstrate that this process requires αvβ5 integrin, rather than αvβ3 integrin utilized by systemic macrophages. Although adult rat RPE expressed both αvβ3 and αvβ5 integrins, only αvβ3 was expressed at birth, when the retina is immature and phago- cytosis is absent. Expression of αvβ5 was first detected in RPE at PN7 and reached adult levels at PN11, just before onset of phagocytic activity. Interestingly, αvβ5 localized in vivo to the apical plasma membrane, facing the photoreceptors, and to intracellular vesicles, whereas αvβ3 was expressed basolat- erally.
机译：视网膜色素上皮（RPE）对脱落的感光细胞杆外部节段（ROS）的吞噬作用对于视网膜功能至关重要。在这里，我们证明该过程需要αvβ5整联蛋白，而不是全身巨噬细胞利用的αvβ3整联蛋白。尽管成年大鼠RPE同时表达αvβ3和αvβ5整联蛋白，但当视网膜不成熟且缺乏吞噬作用时，出生时仅表达αvβ3。在吞噬活性开始之前，首先在PN7的RPE中检测到αvβ5的表达，并在PN11达到成人水平。有趣的是，αvβ5体内定位于顶质膜（面对感光器）和细胞内囊泡，而αvβ3则是在基底细胞中表达的。

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