Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing

Yi Yang; Yan Yang; Harold C. Smith

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Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing

机译：多个蛋白质结构域决定载脂蛋白B mRNA编辑所需的催化亚基的细胞类型特异性核分布

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Apolipoprotein B (apoB) mRNA editing cat- alyzed by apoB mRNA editing catalytic subunit 1 (APOBEC-1) has been proposed to be a nuclear process. To test this hypothesis, the subcellular distribution of hemagglutinin- (HA) tagged APOBEC-1 expressed in transiently transfected hepatoma cells was determined by indirect immunofluores- cence microscopy. HA-APOBEC-1 was detected in both the nucleus and cytoplasm of rat and human hepatoma cells. Mutagenesis of APOBEC-1 demonstrated that the N-terminal 56 amino acids (1-56) were necessary for the nuclear distri- bution of APOBEC-1, but this region did not contain a functional nuclear localization signal (NLS).

机译：载脂蛋白B（apoB）mRNA编辑由apoB mRNA编辑催化亚基1（APOBEC-1）催化，已被认为是一个核过程。为了验证这一假设，通过间接免疫荧光显微镜测定了瞬时转染的肝癌细胞中表达的血凝素（HA）标记的APOBEC-1的亚细胞分布。在大鼠和人肝癌细胞的细胞核和细胞质中均检测到HA-APOBEC-1。 APOBEC-1的诱变表明N末端56个氨基酸（1-56）对于APOBEC-1的核分布是必需的，但是该区域不包含功能性核定位信号（NLS）。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.13075-13080|共6页
作者
Yi Yang; Yan Yang; Harold C. Smith;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Plasma Apolipoprotein B-48, Hepatic Apolipoprotein B mRNA Editing and Apolipoprotein B mRNA Editing Catalytic Subunit-1 mRNA Levels Are Altered in Zinc-Deficient Rats [J] . Scott K. Reaves, Jessica C. Fanzo, John Y. J. Wu, The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 1999,第10期

机译：缺锌大鼠血浆载脂蛋白B-48，肝载脂蛋白B mRNA编辑和载脂蛋白B mRNA编辑催化亚基1 mRNA水平改变
2. Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apolipoprotein B mRNA editing enzyme: functional role in the modulation of apoB mRNA editing. [J] . Funahashi T, Giannoni F, DePaoli AM, Journal of Lipid Research . 1995,第3期

机译：大鼠载脂蛋白B mRNA编辑酶催化亚基的基因的组织特异性，发育和营养调节：在调节apoB mRNA编辑中的功能。
3. The mRNA expression of apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G in peripheral blood mononuclear cells in patients with chronic hepatitis C and its regulation by interferon-α [J] . 蔡卫平中国医学文摘：内科学分册（英文版） . 2013,第001期

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4. Protein Interaction Partners of Protein Phosphatase 2A Catalytic Subunit in Rat β-Islet cells Using Quantitative Mass Spectrometry [C] . Divyasri Damacharla, Khadija Syeda, Xiangmin Zhang, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：使用定量质谱法在大鼠β-胰岛细胞中蛋白质磷酸酶2A催化亚基的蛋白质相互作用伴侣
5. The role of the rhesus macaque (Macaca mulatta) apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) in lentiviral replication and persistence [D] . Schmitt, Kimberly Patricia 2012

机译：恒河猴（猕猴）载脂蛋白B mRNA编辑酶催化多肽样3（APOBEC3）在慢病毒复制和持久性中的作用
6. Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing [O] . Yi Yang, Yan Yang, Harold C. Smith 1997

机译：多个蛋白结构域决定载脂蛋白B mRNA编辑所需的催化亚基的细胞类型特异性核分布
7. C→U Editing of Neurofibromatosis 1 mRNA Occurs in Tumors That Express Both the Type II Transcript and apobec-1, the Catalytic Subunit of the Apolipoprotein B mRNA–Editing Enzyme [O] . Mukhopadhyay Debnath, Anant Shrikant, Lee Robert M., 2002

机译：C→U编辑在表达II型转录物和载脂蛋白B mRNA催化亚基apobec-1的肿瘤中发生神经纤维瘤病1 mRNA表达

Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing

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