Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

Susan E. Hamilton; Michael D. Loose; Ming Qi

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Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

机译：m1受体基因的破坏消除了毒蕈碱受体依赖的M电流调节和小鼠的癫痫发作活性

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Muscarinic acetylcholine receptors are mem- bers of the G protein-coupled receptor superfamily expressed in neurons, cardiomyocytes, smooth muscle, and a variety of epithelia. Five subtypes of muscarinic acetylcholine receptors have been discovered by molecular cloning, but their phar- macological similarities and frequent colocalization make it difficult to assign functional roles for individual subtypes in specific neuronal responses. We have used gene targeting by homologous recombination in embryonic stem cells to pro- duce mice lacking the m1 receptor. These mice show no obvious behavioral or histological defects, and the m2, m3, and m4 receptors continue to be expressed in brain with no evidence of compensatory induction.

机译：毒蕈碱型乙酰胆碱受体是在神经元，心肌细胞，平滑肌和各种上皮细胞中表达的G蛋白偶联受体超家族的成员。通过分子克隆已经发现了5种毒蕈碱型乙酰胆碱受体亚型，但是它们的药理学相似性和频繁的共定位使得难以在特定的神经元反应中为各个亚型分配功能性作用。我们已经通过在胚胎干细胞中进行同源重组来靶向基因，以生产缺乏m1受体的小鼠。这些小鼠没有表现出明显的行为或组织学缺陷，并且在大脑中继续表达m2，m3和m4受体，而没有补偿诱导的证据。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.13311-13316|共6页
作者
Susan E. Hamilton; Michael D. Loose; Ming Qi;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice. [J] . Woolley ML, Carter HJ, Gartlon JE, European Journal of Pharmacology: An International Journal . 2009,第1a3期

机译：非选择性毒蕈碱受体激动剂xanomeline对苯丙胺诱导的活性减弱，在毒蕈碱M4受体敲除小鼠中不存在，而在毒蕈碱M1受体敲除小鼠中则减弱。
2. Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor [J] . E Scarr, M Udawela, E A Thomas, Molecular Psychiatry . 2018,第2期

机译：患有精神分裂症和低皮质毒蕈碱M1受体的受试者中基因表达的改变预示着与该受体相互作用的上游途径被破坏
3. Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor [J] . E Scarr, M Udawela, E A Thomas, Molecular Psychiatry . 2016,第2期

机译：患有精神分裂症和低皮质毒蕈碱M1受体的受试者中基因表达的改变预示着与该受体相互作用的上游途径被破坏
4. Cholinergic Modulation of CA1 Pyramidal Cells via M1 Muscarinic Receptor Activation: A Computational Study at Physiological and Supraphysiological Levels [C] . Adam R. Mergenthal, Jean-Marie C. Bouteiller, Theodore W. Berger Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：通过M1毒蕈碱受体激活对CA1锥体细胞的胆碱能调节：生理和超生理水平的计算研究。
5. M1 muscarinic acetylcholine receptor regulation of endogenous transient receptor potential-canonical, subtype 6 (TRPC6) channels. [D] . Kim, Ju Young. 2005

机译：M1毒蕈碱型乙酰胆碱受体调节内源性瞬时受体电位-典型亚型6（TRPC6）通道。
6. Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice [O] . Susan E. Hamilton, Michael D. Loose, Ming Qi, 1997

机译：m1受体基因的破坏消除了毒蕈碱受体依赖的M电流调节和癫痫发作的作用。
7. Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice [O] . S. E. Hamilton, M. D. Loose, M. Qi, 1997

机译：M1受体基因的破坏消除小鼠的毒蕈碱受体依赖性M常规调节和癫痫发作活性

Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

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