Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway

S. K. Das; Julia A. Taylor; Kenneth S. Korach

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Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway

机译：雌激素受体-α缺陷小鼠的雌激素反应揭示了独特的雌激素信号传导途径

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Estrogens are thought to regulate female reproductive functions by altering gene transcription in target organs primarily via the nuclear estrogen receptor-α (ER-α). By using ER-α "knock-out" (ERKO) mice, we demonstrate herein that a catecholestrogen, 4-hydroxyestradiol-17β (4- OH-E2), and an environmental estrogen, chlordecone (ke- pone), up-regulate the uterine expression of an estrogen- responsive gene, lactoferrin (LF), independent of ER-α. A primary estrogen, estradiol-17β (E2), did not induce this LF response.

机译：人们认为雌激素主要通过核雌激素受体-α（ER-α）改变靶器官中的基因转录来调节女性生殖功能。通过使用ER-α“敲除”（ERKO）小鼠，我们在此处证明了胆囊雌激素4-羟基雌二醇-17β（4- OH-E2）和环境雌激素十氯酮（酮）上调雌激素反应性基因乳铁蛋白（LF）的子宫表达，独立于ER-α。主要的雌激素，雌二醇-17β（E2）不会诱导这种LF反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.12786-12791|共6页
作者
S. K. Das; Julia A. Taylor; Kenneth S. Korach;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus. [J] . Rosenfeld CS, Roberts RM, Lubahn DB Molecular reproduction and development . 2001,第3期

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2. Estrogen upregulates the IGF-1 signaling pathway in lung cancer through estrogen receptor-β [J] . Medical oncology . 2012,第4期

机译：雌激素通过雌激素受体-β上调肺癌的IGF-1信号通路
3. Physiological coupling of growth factor and steroid receptor signaling pathways: Estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor [J] . Sylvia W. Curtis, Todd Washburn, Charles Sewall Proceedings of the National Academy of Sciences of the United States of America . 1996,第22期

机译：生长因子和类固醇受体信号传导途径的生理耦合：雌激素受体敲除小鼠缺乏对表皮生长因子的雌激素样反应
4. Estrogen-Signaling Pathways in Lung Cancer [C] . D.C. Marquez-Garban, R.J. Pietra International Symposium on Hormonal Carcinogenesis . 2008

机译：肺癌中雌激素信号通路
5. SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via inhibition of the phosphoinositide 3-kinases pathway [D] . Moore, Robert L. 2011

机译：SIRT1通过抑制磷酸肌醇3激酶途径抑制雌激素信号传导，配体独立的雌激素受体α介导的转录和乳腺癌细胞的增殖
6. Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway [O] . S. K. Das, Julia A. Taylor, Kenneth S. Korach, 1997

机译：雌激素受体-α缺陷型小鼠的雌激素反应揭示了独特的雌激素信号传导途径
7. Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor. [O] . Curtis, S W, Washburn, T, Sewall, C, 1996

机译：生长因子和类固醇受体信号传导途径的生理耦合：雌激素受体敲除小鼠缺乏对表皮生长因子的雌激素样反应。
8. CSrc and Her2 Signaling Pathways Cooperate With Estrogen to Promote Estrogen Receptor Phosphorylation, Ubiquitination and Proteolysis in ER Negative Breast Cancers [R] . Chu, I. 2006

机译：Csrc和Her2信号通路与雌激素合作促进ER阴性乳腺癌中雌激素受体磷酸化，泛素化和蛋白水解

Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway

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