Anti-idiotype RNA selected with an anti-nuclear export signal antibody is actively transported in oocytes and inhibits Rev- and cap-dependent RNA export

Jorg Hamm; Jochen Huber; Reinhard Luhrmann

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Anti-idiotype RNA selected with an anti-nuclear export signal antibody is actively transported in oocytes and inhibits Rev- and cap-dependent RNA export

机译：用抗核输出信号抗体选择的抗独特型RNA可在卵母细胞中主动转运并抑制Rev和cap依赖性RNA的输出

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The anti-idiotype approach is based on the assumption that an antibody specific for a receptor-binding domain of a ligand could be structurally related to the receptor. Therefore, a structural mimic of a receptor-binding domain, selected with an anti-ligand antibody, might be a functional substrate for the receptor. This hypothesis was addressed here by generating antibodies recognizing the Rev- nuclear export signal (NES). A functional NES is required for active export, presumably by interacting directly or indirectly with the nuclear pore complex. Anti-NES antibodies were used to isolate RNA mimics of the NES peptide from combinatorial RNA libraries.

机译：抗独特型方法基于以下假设：对配体的受体结合结构域具有特异性的抗体可能与受体在结构上相关。因此，用抗配体抗体选择的受体结合结构域的结构模拟物可能是受体的功能底物。通过生成识别Rev-核输出信号（NES）的抗体，解决了这一假设。主动出口需要功能性NES，大概是通过直接或间接与核孔复合体相互作用而实现的。使用抗NES抗体从组合RNA库中分离NES肽的RNA模拟物。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.12839-12844|共6页
作者
Jorg Hamm; Jochen Huber; Reinhard Luhrmann;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Anti-idiotype RNAs that mimic the leucine-rich nuclear export signal and specifically bind to CRM1/exportin 1 [J] . Hamm J., Fornerod M. Chemistry & biology . 2000,第5期

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2. An alternative ELISA for T4 determination based on idiotype anti-idiotype interaction and a latex method for anti-idiotype monoclonal antibody selection. [J] . Becker MI, Aguayo JE, Jamett A, Journal of Immunological Methods . 1996,第1a2期

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3. Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport [J] . Yuan Cao Xinyong Liu Erik De Clercq Current HIV Research . 2009,第1期

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5. Cex1p is a novel component of the Saccharomyces cerevisiae nuclear tRNA export machinery that facilitates dissociation of the tRNA-export receptor complex at the cytoplasmic face of the nuclear pore complex. [D] . McGuire, Andrew T. 2011

机译：Cex1p是啤酒酵母核tRNA出口机制的新型组件，可促进tRNA出口受体复合物在核孔复合体的胞质面上解离。
6. Anti-idiotype RNA selected with an anti-nuclear export signal antibody is actively transported in oocytes and inhibits Rev- and cap-dependent RNA export [O] . Jörg Hamm, Jochen Huber, Reinhard Lührmann 1997

机译：用抗核输出信号抗体选择的抗独特型RNA可在卵母细胞中主动转运并抑制依赖Rev和cap的RNA的输出
7. Anti-idiotype RNAs that mimic the leucine-rich nuclear export signal and specifically bind to CRM1/exportin 1 [O] . Hamm Jörg, Fornerod Maarten 2000

机译：模仿富含亮氨酸的核输出信号并特异性结合CRM1 / exportin 1的抗独特型RNA
8. Export Sales and Assistance Project: Tennessee Export Guide and Services Directory; Tennessee International Trade Directory; TCEC (Tennessee Competitive Export Corporation) Brochure [R] . 1984

机译：出口销售和援助项目：田纳西州出口指南和服务目录;田纳西州国际贸易指南; TCEC（田纳西州竞争性出口公司）手册

Anti-idiotype RNA selected with an anti-nuclear export signal antibody is actively transported in oocytes and inhibits Rev- and cap-dependent RNA export

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