Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl- CoA reductase

Randolph Y. Hampton; Hetal Bhakta

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Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl- CoA reductase

机译：泛素介导的3-羟基-3-甲基戊二酰辅酶A还原酶的调节

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Regulation of the sterol-synthesizing meval- onate pathway occurs in part through feedback-regulated endoplasmic reticulum degradation of 3-hydroxy-3-methyl- glutaryl-CoA reductase (HMG-R). In yeast, the Hmg2p isozyme of HMG-R is regulated in this manner. We have tested the involvement of ubiquitination in the regulated degradation of Hmg2p, by using both genetic and direct biochemical approaches. Hmg2p degradation required the UBC7 gene, and Hmg2p protein was directly ubiquitinated. Hmg2p ubiquiti- nation was dependent on UBC7 and was specific for the degraded yeast Hmg2p isozyme.

机译：固醇合成的半乳糖酸酯途径的调节部分通过反馈调节的3-羟基-3-甲基-戊二酰辅酶A还原酶（HMG-R）的内质网降解而发生。在酵母中，以这种方式调节HMG-R的Hmg2p同工酶。我们已经通过使用遗传和直接生化方法测试了泛素化参与Hmg2p调控的降解。 Hmg2p降解需要UBC7基因，并且Hmg2p蛋白直接泛素化。 Hmg2p的普遍存在依赖于UBC7，并且对降解的酵母Hmg2p同工酶具有特异性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.12944-12948|共5页
作者
Randolph Y. Hampton; Hetal Bhakta;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：下调胆固醇水平的生物合成胆固醇：乙酰乙酰-CoA硫解酶，3-羟基-3-甲基戊二酰-CoA合酶，还原酶，角鲨烯合酶和7-脱氢胆固醇delta7-还原酶的活性降低
2. Transcriptional Regulation of HMG-CoA Synthase and HMG-CoA Reductase Genes by Human ACBP [J] . Vock C, Doring F, Nitz I Cellular Physiology and Biochemistry . 2008,第5a6期

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5. HMG -CoA reductase: Protein regulation by a quality control pathway [D] . Shearer, Alexander Glennon 2004

机译：HMG-CoA还原酶：通过质量控制途径进行蛋白质调控
6. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase [O] . Randolph Y. Hampton, Hetal Bhakta 1997

机译：泛素介导的3-羟基-3-甲基戊二酰辅酶A还原酶的调节
7. Transcriptional Regulation of HMG-CoA Synthase and HMG-CoA Reductase Genes by Human ACBP [O] . Christina Vock, Frank Döring, Inke Nitz 2008

机译：人ACBP的HMG-COA合酶和HMG-COA还原酶基因的转录调节

Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl- CoA reductase

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