Siamois is required for formation of Spemann's organizer

Daniel S. Kessler

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Siamois is required for formation of Spemann's organizer

机译：成立Spemann组织者需要Siamois

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Spemann's organizer develops in response to dorsal determinants that act via maternal components of the wnt pathway. The function of siamois, a wnt-inducible ho- meobox gene, in Spemann's organizer development was ex- amined by fusion of defined transcriptional regulatory do- mains to the siamois homeodomain. Similar to native siamois, a VP16 activator fusion induced axis formation, indicating that siamois functions as a transcriptional activator in axis induction. Fusion of the engrailed repressor generated a dominant inhibitor that blocked axis induction by Xwnt8, β-catenin, and siamois, and repressed wnt activation of the goosecoid promoter.

机译：Spemann的组织者是根据通过wnt途径的母体成分起作用的背侧决定因素而发展的。通过将确定的转录调控域融合到siamois同源结构域中，研究了smomann基因在Spemann组织发育中的作用。类似于天然暹罗，VP16激活剂融合诱导了轴的形成，表明暹罗在轴诱导中起转录激活剂的作用。复杂的阻遏物的融合产生了显性抑制剂，该抑制剂阻滞了Xwnt8，β-catenin和siamois的轴诱导，并抑制了鹅状启动子的wnt激活。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.13017-13022|共6页
作者
Daniel S. Kessler;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Siamois and Twin are redundant and essential in formation of the Spemann organizer. [J] . Bae S, Reid CD, Kessler DS Developmental biology . 2011,第2期

机译：Siamois和Twin是多余的，对于Spemann组织者的形成至关重要。
2. Siamois and Twin are redundant and essential in formation of the Spemann organizer [J] . Sangwoo Bae, Christine D. Reid, Daniel S. Kessler Developmental biology . 2011,第2期

机译：Siamois和Twin是多余的，对于Spemann组织者的形成至关重要
3. Molecular link in the sequential induction of the Spemann organizer: direct activation of the cerberus gene by Xlim-1, Xotx2, Mix.1, and Siamois, immediately downstream from Nodal and Wnt signaling [J] . Yamamoto S., Hikasa H., Ono H., Developmental biology . 2003,第1期

机译：Spemann组织者的顺序诱导中的分子联系：通过Xlim-1，Xotx2，Mix.1和Siamois，直接在Nodal和Wnt信号的下游激活cerberus基因
4. Self-organizing by Information Maximization: Realizing Self-Organizing Maps by Information-Theoretic Competitive Learning [C] . Ryotaro Kamimura Neural Information Processing pt.1; Lecture Notes in Computer Science; 4232 . 2006

机译：通过信息最大化进行自组织：通过信息理论竞争学习实现自组织地图
5. Formation of the Spemann organizer in Xenopus laevis. [D] . Vodicka, Marie Anne. 1995

机译：Xenopus laevis中Spemann组织者的形成。
6. Siamois is required for formation of Spemann’s organizer [O] . Daniel S. Kessler 1997

机译：成立Spemann组织者需要Siamois
7. Siamois and Twin are redundant and essential in formation of the Spemann organizer [O] . Bae Sangwoo, Reid Christine D., Kessler Daniel S. 2011

机译：Siamois和Twin是多余的，对于Spemann组织者的形成至关重要

Siamois is required for formation of Spemann's organizer

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