All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

Kara Dolinski; Scott Muir; Maria Cardenas

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All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

机译：所有亲环蛋白和FK506结合蛋白对于酿酒酵母的生存力都是单独的和共同的

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The cyclophilins and FK506 binding proteins (FKBPs) bind to cyclosporin A, FK506, and rapamycin and mediate their immunosuppressive and toxic effects, but the phys- iological functions of these proteins are largely unknown. Cyclo- philins and FKBPs are ubiquitous and highly conserved enzymes that catalyze peptidyl-prolyl isomerization, a rate-limiting step during in vitro protein folding. We have addressed their functions by a genetic approach in the yeast Saccharomyces cerevisiae. Five cyclophilins and three FKBPs previously were identified in yeast.

机译：亲环蛋白和FK506结合蛋白（FKBPs）与环孢菌素A，FK506和雷帕霉素结合并介导其免疫抑制和毒性作用，但这些蛋白的生理功能尚不清楚。亲环素和FKBP是普遍存在且高度保守的酶，可催化肽基脯氨酰异构化，这是体外蛋白质折叠过程中的限速步骤。我们已经通过遗传方法在酿酒酵母中解决了它们的功能。以前在酵母中鉴定出五个亲环蛋白和三个FKBP。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第24期|p.13093-13098|共6页
作者
Kara Dolinski; Scott Muir; Maria Cardenas;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. N-terminal disordered domain of saccharomyces cerevisiae Hop1 protein is dispensable for DNA binding, bridging, and synapsis of double-stranded DNA molecules but is necessary for spore formation [J] . Khan K., Vipin Madhavan T.P., Kshirsagar R., Biochemistry . 2013,第31期

机译：酿酒酵母Hop1蛋白的N端无序域可用于DNA结合，桥接和突触双链DNA分子，但对于孢子形成是必不可少的
2. Isolation of mannan-protein complexes from viable cells of Saccharomyces cerevisiae X2180-1A wild type and Saccharomyces cerevisiae X2180-1 A-5 mutant strains by the action of Zymolyase-60,000. [J] . N Shibata, K Mizugami, K Takano, Journal of bacteriology . 1983,第2期

机译：通过Zymolyase-60,000的作用，从酿酒酵母X2180-1A野生型和酿酒酵母X2180-1 A-5突变株的活细胞中分离甘露聚糖蛋白复合物。
3. Partial dispensability of Djp1's J domain in peroxisomal protein import in Saccharomyces cerevisiae results from genetic redundancy with another class II J protein, Caj1 [J] . Neha Dobriyal, Prerna Tripathi, Susrita Sarkar, Cell stress & chaperones . 2017,第3期

机译：Djp1的J结构域在酿酒酵母过氧化物酶体蛋白导入中的部分可分配性是由于与另一种II类J蛋白Caj1的遗传冗余造成的
4. A Stress Response Comparison: LC/MS metabolomics analysis of Saccharomyces cerevisiae exposed to the immunosuppressant drugs FK506 and Cyclosporin A [C] . Stefan Jenkins, Theodore R. Sana, Lily Chen American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：应力响应比较：LC / MS代谢组科分析酿酒酵母暴露于免疫抑制药物FK506和环孢菌素A.
5. The redesign of a type 2 into a type 1 copper protein: Construction, expression, purification and characterization of metal-binding site mutant proteins of copper, zinc superoxide dismutase from Saccharomyces cerevisiae [D] . Lu, Yi. 1992

机译：将2型转变为1型铜蛋白：啤酒酵母中铜，锌超氧化物歧化酶的金属结合位点突变蛋白的构建，表达，纯化和表征
6. All cyclophilins and FK506 binding proteins are individually and collectively dispensable for viability in Saccharomyces cerevisiae [O] . Kara Dolinski, Scott Muir, Maria Cardenas, 1997

机译：所有亲环蛋白和FK506结合蛋白对于酿酒酵母中的生存力都是单独的和共同的
7. FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins. [O] . Wiederrecht, G, Brizuela, L, Elliston, K, 1991

机译：FKB1在酿酒酵母中编码非必需的FK 506结合蛋白，并含有暗示与亲环蛋白同源的区域。
8. Low-Molecular-Weight, Cobalt-Binding Proteins from Saccharomyces Cerevisiae and Bacillus Subtilis [R] . Leeper, S. A., Wolfram, J. H., Ward, T. E. 1985

机译：来自酿酒酵母和枯草芽孢杆菌的低分子量钴结合蛋白

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

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