Syntenin, a PDZ protein that binds syndecan cytoplasmic domains

Johan J. Grootjans; Pascale Zimmermann; Gunter Reekmans

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Syntenin, a PDZ protein that binds syndecan cytoplasmic domains

机译：Syntenin，一种结合syndecan细胞质结构域的PDZ蛋白

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The syndecans are transmembrane proteo- glycans that place structurally heterogeneous heparan sulfate chains at the cell surface and a highly conserved polypeptide in the cytoplasm. Their versatile heparan sulfate moieties support various processes of molecular recognition, signaling, and trafficking. Here we report the identification of a protein that binds to the cytoplasmic domains of the syndecans in yeast two-hybrid screens, surface plasmon resonance experi- ments, and ligand-overlay assays. This protein, syntenin, contains a tandem repeat of PDZ domains that reacts with the FYA C-terminal amino acid sequence of the syndecans.

机译：合成聚糖是跨膜蛋白聚糖，其在结构上将异质硫酸乙酰肝素链置于细胞表面，并将高度保守的多肽置于细胞质中。它们的多功能硫酸乙酰肝素部分支持分子识别，信号传导和运输的各种过程。在这里，我们报道了一种在酵母双杂交筛选，表面等离振子共振实验和配体重叠测定中与结合蛋白的胞质结构域结合的蛋白质的鉴定。这种蛋白，即Stentenin，包含PDZ结构域的串联重复序列，该序列与Syndecan的FYA C末端氨基酸序列反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第25期|p.13683-13688|共6页
作者
Johan J. Grootjans; Pascale Zimmermann; Gunter Reekmans;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97. [J] . Dirks P, Thomas U, Montag D The European Journal of Neuroscience . 2006,第1期

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2. Processing of heparanase is mediated by syndecan?1 cytoplasmic domain and involves syntenin and α?actinin [J] . Anna Shteingauz, Neta Ilan, Israel Vlodavsky Cellular and molecular life sciences: CMLS . 2014,第22期

机译：乙酰肝素酶的加工过程由syndecan？1胞质域介导，涉及syntenin和α？actinin
3. Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1. [J] . Lee H, Kim Y, Choi Y, Biochemical and Biophysical Research Communications . 2011,第1期

机译：Syndecan-2胞质域通过与syntenin-1相互作用调节结肠癌细胞的迁移。
4. Protein interaction prediction for mouse pdz domains using dipeptide composition features [C] . Nakariyakul Songyot, Liu Zhi-Ping, Chen Luonan 2011 IEEE International Conference on Systems Biology . 2011

机译：使用二肽组成特征预测小鼠pdz域的蛋白质相互作用
5. I. Design, synthesis, and characterization of peptides for thermodynamic binding studies of PDZ protein interaction domains II. DNA cytosine deaminases and the development of assays to study uracil in the genome. [D] . Parisien, Rachel B. 2010

机译：I.用于PDZ蛋白相互作用域的热力学结合研究的肽的设计，合成和表征。 DNA胞嘧啶脱氨酶和研究基因组中尿嘧啶的测定方法的发展。
6. Syntenin a PDZ protein that binds syndecan cytoplasmic domains [O] . Johan J. Grootjans, Pascale Zimmermann, Gunter Reekmans, 1997

机译：Syntenin一种结合syndecan细胞质plasm结构域的PDZ蛋白
7. Tyrosine Dephosphorylation of the Syndecan-1 PDZ Binding Domain Regulates Syntenin-1 Recruitment* [O] . Sulka, Béatrice, Lortat-Jacob, Hugues, Terreux, Raphael, 2009

机译：Syndecan-1 PDZ结合域的酪氨酸去磷酸化调节。 Syntenin-1 招聘*

Syntenin, a PDZ protein that binds syndecan cytoplasmic domains

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