WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

Narayanaswamy Ramesh; Ines M. Anton; John H. Hartwig

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WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

机译：WIP是一种与Wiskott-Aldrich综合征蛋白相关的蛋白，可诱导肌动蛋白聚合并在淋巴样细胞中重新分布

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Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency caused by mutations that affect the WAS protein (WASP) and characterized by cytoskeletal abnormalities in hematopoietic cells. By using the yeast two-hybrid system we have identified a proline-rich WASP- interacting protein (WIP), which coimmunoprecipitated with WASP from lymphocytes. WIP binds to WASP at a site distinct from the Cdc42 binding site and has actin as well as profilin binding motifs. Expression of WIP in human B cells, but not of a WIP truncation mutant that lacks the actin binding motif, increased polymerized actin content and induced the appearance of actin-containing cerebriform projections on the cell surface. These results suggest that WIP plays a role in cortical actin assembly that may be important for lymphocyte function.

机译：Wiskott-Aldrich综合征（WAS）是一种X连锁免疫缺陷，由影响WAS蛋白（WASP）的突变引起，并以造血细胞的细胞骨架异常为特征。通过使用酵母双杂交系统，我们鉴定了富含脯氨酸的WASP相互作用蛋白（WIP），该蛋白与淋巴细胞中的WASP共免疫沉淀。 WIP在与Cdc42结合位点不同的位点与WASP结合，并具有肌动蛋白和蛋白原结合蛋白。 WIP在人B细胞中的表达，但不是缺少肌动蛋白结合基序的WIP截断突变体，不会增加聚合肌动蛋白的含量，并诱导细胞表面上含肌动蛋白的脑形突起的出现。这些结果表明，WIP在可能对淋巴细胞功能重要的皮质肌动蛋白组装中发挥作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第26期|p.14671-14676|共6页
作者
Narayanaswamy Ramesh; Ines M. Anton; John H. Hartwig;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding. [J] . Massaad MJ, Ramesh N, Le Bras S, The Journal of Allergy and Clinical Immunology . 2011,第4期

机译：来自Wiskott-Aldrich综合征（WAS）蛋白相互作用蛋白（WIP）的肽可以恢复WAS突变患者的淋巴细胞中的WAS蛋白水平和肌动蛋白细胞骨架重组，从而破坏WIP结合。
2. The Novel Adaptor Protein, Mti1p, and Vrp1p, a Homolog of Wiskott-Aldrich Syndrome Protein-Interacting Protein (WIP), May Antagonistically Regulate Type I Myosins in Saccharomyces cerevisiae [J] . Junko Mochida, Kazuma Tanaka, Konomi Fujimura-Kamada, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2002,第3期

机译：Wiskott-Aldrich综合征蛋白相互作用蛋白（WIP）的同系物，新的衔接蛋白Mti1p和Vrp1p可能拮抗啤酒酵母中的I型肌球蛋白。
3. The Wiskott-Aldrich Syndrome Protein Regulates Nuclear Translocation of NFAT2 and NF-κB (RelA) Independently of Its Role in Filamentous Actin Polymerization and Actin Cytoskeletal Rearrangement [J] . Winifred Huang, Hans D. Ochs, Bo Dupont, The journal of immunology . 2005,第8期

机译：Wiskott-Aldrich综合征蛋白独立于其在丝状肌动蛋白聚合和肌动蛋白细胞骨架重排中的作用，调节NFAT2和NF-κB（RelA）的核易位。
4. Studying Actin Binding Proteins and the Interaction of Drugs with the Actin Hydrophobic Cleft by ESI-MS [C] . Sabrina A. Benchaar, Shirley H. Lomeli, Alexander Shvetsov, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：ESI-MS研究肌动蛋白结合蛋白及药物与肌动蛋白疏水裂缝的相互作用
5. The Role of the Wiskott-Aldrich Syndrome Protein in Regulating T Cell Programmed Cell Death Mechanisms and Implications for Autoimmunity in the Wiskott-Aldrich Syndrome. [D] . Marjanovic, Sophia Y. 2016

机译：Wiskott-Aldrich综合征蛋白在调节T细胞程序性细胞死亡机制中的作用以及Wiskott-Aldrich综合征自身免疫的影响。
6. WIP a protein associated with Wiskott–Aldrich syndrome protein induces actin polymerization and redistribution in lymphoid cells [O] . Narayanaswamy Ramesh, Inés M. Antón, John H. Hartwig, 1997

机译：WIP是一种与Wiskott-Aldrich综合征蛋白相关的蛋白可诱导肌动蛋白聚合并在淋巴样细胞中重新分布
7. Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein* [O] . Zhang, Juan, Zhang, Xiaofei, Guo, Yunqian, 2009

机译：通过与Wiskott-Aldrich综合征蛋白相互作用，分选Nexin 33诱导哺乳动物细胞微核表型和肌动蛋白聚合*

WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

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