Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

Kanji Yoshida; Tetsuya Taga; Mikiyoshi Saito

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

【24h】

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

机译：gp130的靶向性破坏是白介素6家族细胞因子的常见信号转导因子，可导致心肌和血液系统疾病

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

gp130 is a ubiquitously expressed signal- transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1. To investi- gate physiological roles of gp130 and to examine pathological consequences of a lack of gp130, mice deficient for gp130 have been prepared. Embryos homozygous for the gp130 mutation progressively die between 12.5 days postcoitum and term.

机译：gp130是白介素6，白介素11，白血病抑制因子，抑癌素M，睫状神经营养因子和心肌营养素1共有的普遍表达的信号转导受体成分。研究gp130的生理作用并检查缺乏gp130的病理后果gp130，已经制备了gp130缺陷的小鼠。 gp130突变的纯合子胚胎在分娩后和足月12.5天之间逐渐死亡。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第1期|p.407-411|共5页
作者
Kanji Yoshida; Tetsuya Taga; Mikiyoshi Saito;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. [J] . Yanagisawa M, Nakashima K, Arakawa H, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2000,第4期

机译：通过激活常见的细胞因子信号转导子gp130和转录因子STAT3，通过白介素11使胎儿神经上皮细胞星形胶质细胞分化。
2. Differential stimulation-induced receptor localization in lipid rafts for interleukin-6 family cytokines signaling through the gp130/leukemia inhibitory factor receptor complex. [J] . Port MD, Gibson RM, Nathanson NM Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2007,第3期

机译：通过gp130 /白血病抑制因子受体复合物介导的白介素6家族细胞因子信号传导在脂质筏中的差异刺激诱导受体定位。
3. The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines. [J] . Maes M, Libbrecht I, Van Hunsel-F, Psychoneuroendocrinology: An International Journal . 1999,第4期

机译：纤维肌痛的免疫炎症病理生理学：血清可溶性gp130升高，这是各种神经营养细胞因子的常见信号转导蛋白。
4. Termination and modulation of interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway [C] . P. C. HEINRICH, I. BEHRMANN, J. G. BODE, Falk Symposium . 2000

机译：通过GP130 / JAK /统计途径终止和调节白细胞介素-6型细胞因子信号传导
5. A Cytokine Odyssey: From Interleukin-2 Signaling to Cytokine Therapy for Cancer. [D] . Tran, Eric. 2013

机译：细胞因子的奥德赛：从白介素2信号转导到细胞因子的癌症治疗。
6. Targeted disruption of gp130 a common signal transducer for the interleukin 6 family of cytokines leads to myocardial and hematological disorders. [O] . K Yoshida, T Taga, M Saito, 1996

机译：gp130（白介素6细胞因子家族的常见信号转导子）的靶向破坏会导致心肌和血液系统疾病。
7. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. [O] . Yoshida, K, Taga, T, Saito, M, 1996

机译：gp130（白介素6细胞因子家族的常见信号转导子）的靶向破坏会导致心肌和血液系统疾病。

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

摘要

著录项

相似文献

相关主题

期刊订阅