Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets

Toufic O. Nashar; Helen M. Webb; Simon Eaglestone

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Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets

机译：大肠杆菌热不稳定肠毒素B亚基的强免疫原性：受体结合是必不可少的，并诱导淋巴细胞亚群的差异调节

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The importance of receptor binding in the potent immunogenicity of Escherichia coli heat-labile entero- toxin B subunit (EtxB) was tested by comparing its immu- nogical properties with those of a receptor binding mutant, EtxB(G33D). Subcutaneous immunization of EtxB(G33D) resulted in 160-fold reduction in antibody titer compared with wild-type EtxB, whereas its oral delivery failed to provoke any detectable secretory or serum anti-B subunit responses.

机译：通过将其免疫特性与受体结合突变体EtxB（G33D）的免疫特性进行比较，测试了受体结合在大肠杆菌热不稳定肠毒素B亚基（EtxB）的强免疫原性中的重要性。与野生型EtxB相比，EtxB（G33D）的皮下免疫导致抗体滴度降低160倍，而其口服给药未能引起任何可检测的分泌或血清抗B亚基反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第1期|p.226-230|共5页
作者
Toufic O. Nashar; Helen M. Webb; Simon Eaglestone;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Modulation of B lymphocyte signalling by the B subunit of Escherichia coli heat-labile enterotoxin. [J] . Bone H, Eckholdt S, Williams NA International immunology. . 2002,第6期

机译：大肠杆菌热不稳定肠毒素的B亚基对B淋巴细胞信号的调节。
2. Prevention of autoimmune disease due to lymphocyte modulation by the B-subunit of Escherichia coli heat-labile enterotoxin [J] . Neil A. Williams, Lisa M. Stasiuk, Toufic O. Nashar Proceedings of the National Academy of Sciences of the United States of America . 1997,第10期

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3. Importance of receptor binding in the immunogenicity, adjuvanticity and therapeutic properties of cholera toxin and Escherichia coli heat-labile enterotoxin. [J] . Nashar TO ristol.ac.uk, Williams NA, Hirst TR Medical Microbiology and Immunology . 1998,第1期

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5. Evaluation of low dose exposure and immunogenicity of transgenic maize expressing the Escherichia coli heat-labile toxin B subunit when fed intermittently and daily. [D] . Beyer, April Jean. 2007

机译：间歇性和每日饲喂表达大肠杆菌热不稳定毒素B亚基的转基因玉米的低剂量暴露和免疫原性评估。
6. Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets. [O] . T O Nashar, H M Webb, S Eaglestone, 1996

机译：大肠杆菌热不稳定肠毒素的B亚基的强免疫原性：受体结合必不可少并诱导淋巴细胞亚群的差异调节。
7. Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets. [O] . Nashar, T O, Webb, H M, Eaglestone, S, 1996

机译：大肠杆菌热不稳定肠毒素的B亚基的强免疫原性：受体结合必不可少，并诱导淋巴细胞亚群的差异调节。
8. Plasmids Coding for Colonization Factor Antigens I and II, Heat-Labile Enterotoxin, and Heat-Stable Enterotoxin A2 in Escherichia coli [R] . Echeverria, P., Seriwatana, J., Taylor, D. N., 1986

机译：质粒编码在大肠杆菌中的定殖因子抗原I和II，热不稳定肠毒素和热稳定肠毒素a2

Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets

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