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Muller's ratchet decreases fitness of a DNA-based microbe

机译:穆勒的棘轮降低了基于DNA的微生物的适应性

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摘要

Muller proposed that an asexual organism will inevitably accumulate deleterious mutations, resulting in an increase of the mutational load and an inexorable, ratchet- like, loss of the least mutated class [Muller, H. J. (1964) Mutat. Res. 1, 2-9]. The operation of Muller's ratchet on real popu- lations has been experimentally demonstrated only in RNA viruses. However, these cases are exceptional in that the mutation rates of the RNA viruses are extremely high.
机译:穆勒(Muller)提出无性生物将不可避免地积累有害的突变,从而导致突变量的增加和不可避免的,棘轮状的,最少突变的类别的丧失[Muller,H. J.(1964)Mutat。Chem。,1987,53,1939-1959。 Res。 1,2-9]。穆勒棘轮对真实人群的操作仅在RNA病毒中得到了实验证明。然而,这些情况是例外的,因为RNA病毒的突变率极高。

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