Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

Dylan Daniel; Dale R. Wegmann

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Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

机译：通过鼻内或皮下注射胰岛素肽B-（9-23）保护非肥胖糖尿病小鼠免于糖尿病

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The observation that overt type I diabetes is often preceded by the appearance of insulin autoantibodies and the reports that prophylactic administration of insulin to biobreeding diabetes-prone (BB-DP) rats, nonobese diabetic (NOD) mice, and human subjects results in protection from diabetes suggest that an immune response to insulin is in- olved in the process of beta cell destruction.

机译：普遍存在I型糖尿病的观察通常是在出现胰岛素自身抗体之前，并且有报道指出，对易生生物糖尿病（BB-DP）大鼠，非肥胖糖尿病（NOD）小鼠和人类受试者预防性给予胰岛素治疗的报道糖尿病提示在β细胞破坏过程中引入了对胰岛素的免疫反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第2期|p.956-960|共5页
作者
Dylan Daniel; Dale R. Wegmann;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Comparative Study of Oral versus Subcutaneous B:9-23 Insulin Peptide in Balb/c Mice as an Experimental Model for Autoimmune Diabetes [J] . DEVASENAN DEVENDRA, JOHANNA PARONEN, EDWIN LIU, Annals of the New York Academy of Sciences . 2004,第Dec期

机译：Balb / c小鼠口服和皮下B：9-23胰岛素肽作为自身免疫性糖尿病实验模型的比较研究
2. Combined insulin B : 9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4(+)Foxp3(+) regulatory T cells in the islets in non-obese diabetic mice [J] . Fukushima K, Abiru N, Nagayama Y, Biochemical and Biophysical Research Communications . 2008,第4期

机译：胰岛素B组合：9-23自肽和多肌苷-聚胞苷酸可加速胰岛素抵抗，但可通过增加非肥胖糖尿病小鼠胰岛中CD4（+）Foxp3（+）调节性T细胞的比例来抑制糖尿病的发展
3. Oral administration of insulin to female nonobese diabetic mice inhibited diabetes and induced Fas ligand expression on islets of Langerhans [J] . WANG Heng, LI Yuxiu, SUN Qi 20f Chinese Medical Journal . 2000,第5期

机译：对雌性非肥胖糖尿病小鼠口服胰岛素可抑制糖尿病并诱导Langerhans胰岛Fas配体表达
4. Mathematical model of postprandial glucose-insulin metabolism in insulin dependent diabetics with subcutaneous and intravenous insulin administration routes [C] . Yamamoto Cecilia, Furutani Eiko, Sumi Shoichiro SICE Annual Conference 2011 : Final program and abstracts . 2011

机译：胰岛素依赖型糖尿病患者皮下和静脉内胰岛素给药途径的餐后葡萄糖-胰岛素代谢数学模型
5. The absence of CD62L (L-selectin) does not inhibit the progression of autoimmune diabetes in nonobese diabetic (NOD) mice. [D] . Friedline, Randall Henry. 2001

机译：在非肥胖糖尿病（NOD）小鼠中，CD62L（L-选择素）的缺乏不会抑制自身免疫性糖尿病的进展。
6. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). [O] . D Daniel, D R Wegmann 1996

机译：通过鼻内或皮下注射胰岛素肽B-（9-23）保护非肥胖糖尿病小鼠免于糖尿病。
7. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). [O] . Daniel, D, Wegmann, D R 1996

机译：通过鼻内或皮下注射胰岛素肽B-（9-23），保护非肥胖糖尿病小鼠免于糖尿病。

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

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