Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys

B. L. Murphy; A. F. T. Arnsten; P. S. Goldman-Rakic

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Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys

机译：前额叶皮质中多巴胺转换增加会损害大鼠和猴子的空间工作记忆性能

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The selective activation of the prefrontal cortical dopamine system by mild stress can be mimicked by anxiogenic β-carbolines such as FG7142. To investigate the functional relevance of elevated levels of dopamine turnover in the prefrontal cortex, the current study examined the effects of FG7142 on the performance of spatial working memory tasks in the rat and monkey. FG7142 selectively increased prefrontal cortical dopamine turnover in rats and signify- cantly impaired performance on spatial working memory tasks in both rats and monkeys.

机译：轻度应激可选择性激活前额叶皮层多巴胺系统，这可以通过产生焦虑的β-咔啉（例如FG7142）来模拟。为了研究前额叶皮层中多巴胺转换水平升高的功能相关性，当前研究检查了FG7142对大鼠和猴子空间工作记忆任务的执行效果。 FG7142有选择地增加了大鼠前额叶皮质多巴胺的代谢，并显着削弱了大鼠和猴子在空间工作记忆任务中的表现。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第3期|p.1325-1329|共5页
作者
B. L. Murphy; A. F. T. Arnsten; P. S. Goldman-Rakic;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Chronic NMDA Antagonism Impairs Working Memory, Decreases Extracellular Dopamine, and Increases D1 Receptor Binding in Prefrontal Cortex of Conscious Monkeys [J] . Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Neuropsychopharmacology . 2005,第10期

机译：慢性NMDA拮抗作用损害工作记忆，减少细胞外多巴胺，并增加清醒猴子前额叶皮层中的D1受体结合。
2. The Alpha-2A-Adrenoceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory Task [J] . Robert A Avery, Jenna S Franowicz, Colin Studholme, Neuropsychopharmacology . 2000,第3期

机译：Alpha-2A-肾上腺素受体激动剂，胍法辛，增加执行空间工作记忆任务的猴子的背外侧前额叶皮层的局部脑血流量
3. Nicotine Normalizes Increased Prefrontal Cortical Dopamine D1 Receptor Binding and Decreased Working Memory Performance Produced by Repeated Pretreatment with MK-801: A PET Study in Conscious Monkeys [J] . Hideo Tsukada, Katsumasa Miyasato, Shingo Nishiyama, Neuropsychopharmacology . 2005,第12期

机译：尼古丁使增加的前额叶皮质多巴胺D1受体结合正常化，并通过重复预处理MK-801降低工作记忆性能：在有意识的猴子中进行PET研究
4. Neuronal activity in monkey prefrontal cortex representing working memory of abstract rule in an analog of Wisconsin Card Sorting Test (WCST) [C] . Keiji Tanaka International conference on cognitive science;ICCS 2001 . 2001

机译：猴子前额叶皮层中的神经元活动代表威斯康星卡片分类测试（WCST）类似物的抽象规则工作记忆
5. The role of rat medial prefrontal cortex in spatial working memory. [D] . Horst, Nicole Kristen. 2009

机译：大鼠内侧前额叶皮层在空间工作记忆中的作用。
6. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. [O] . B L Murphy, A F Arnsten, P S Goldman-Rakic, 1996

机译：前额叶皮层中多巴胺转换的增加损害了大鼠和猴子的空间工作记忆性能。
7. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. [O] . Murphy, B L, Arnsten, A F, Goldman-Rakic, P S, 1996

机译：前额叶皮层中多巴胺转换的增加损害了大鼠和猴子的空间工作记忆性能。

Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys

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