Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli

Isabel Mellon; Gregory N. Champe

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Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli

机译：DNA错配修复基因mutS和mutL的产物是大肠杆菌中乳糖操纵子的转录偶联核苷酸切除修复所必需的

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To improve our understanding of the mech- anism that couples nucleotide-excision repair to transcription in expressed genes, we have examined the effects of mutations in several different DNA repair genes on the removal of cyclobutane pyrimidine dimers from the individual strands of the induced lactose operon in UV-irradiated Escherichia coli. As expected, we found little repair in either strand of the lactose operon in strains with mutations in established nu- cleotide excision-repair genes (uvrA, uvrB, uvrC, or uvrD).

机译：为了增进我们对将核苷酸切除修复与表达基因的转录耦合的机制的理解，我们研究了几种不同DNA修复基因的突变对从诱导的乳糖操纵子的单链上去除环丁烷嘧啶二聚体的影响。在紫外线辐射的大肠杆菌中。如预期的那样，在已建立核苷酸切除修复基因（uvrA，uvrB，uvrC或uvrD）突变的菌株中，乳糖操纵子的任一链修复都很少。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第3期|p.1292-1297|共6页
作者
Isabel Mellon; Gregory N. Champe;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function [J] . Quaresima B., Alifano P., Tassone P., The Biochemical Journal . 2003,第0期

机译：人错配修复蛋白MutL同源物1（MLH1）在体内和体外与大肠杆菌MutL和MutS相互作用：一种简单的遗传系统，可检测MLH1功能
2. Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function [J] . Quaresima B., Alifano P., Tassone P., The Biochemical Journal . 2003,第0期

机译：人错配修复蛋白MutL同源物1（MLH1）在体内和体外与大肠杆菌MutL和MutS相互作用：一种简单的遗传系统，可检测MLH1功能
3. Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function [J] . Barbara QUARESIMA, Enrico V. AVVEDIMENTO, Francesco S. COSTANZO, The biochemical journal . 2003,第1期

机译：人错配修复蛋白MutL同源物1（MLH1）在体内和体外与大肠杆菌MutL和MutS相互作用：一种简单的遗传系统，可检测MLH1功能
4. High expression and identification of DNA mismatch repair gene mutSin Escherichia coli [C] . The Seventh China-Japan joint symposium on enzyme engineering . 2002

机译：DNA错配修复基因mutSin在大肠杆菌中的高表达与鉴定
5. Regulation and expression of an overlapping gene, vsr, required for very short patch repair in Escherichia coli [D] . Dar, Mubasher Ehsan 1993

机译：大肠杆菌中非常短的补丁修复所需的重叠基因vsr的调控和表达
6. Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli. [O] . I Mellon, G N Champe 1996

机译：DNA错配修复基因mutS和mutL的产物是大肠杆菌中乳糖操纵子的转录偶联核苷酸切除修复所必需的。
7. Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli. [O] . Mellon, I, Champe, G N 1996

机译：DNA错配修复基因mutS和mutL的产物是大肠杆菌中乳糖操纵子的转录偶联核苷酸切除修复所必需的。

Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli

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