Antiproliferative properties of the USF family of helix-loop-helix transcription factors

Xu Luo; Michele Sawadogo

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Antiproliferative properties of the USF family of helix-loop-helix transcription factors

机译：USF螺旋-环-螺旋转录因子家族的抗增殖特性

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USF is a family of transcription factors characterized by a highly conserved basic-helix-loop-helix- leucine zipper (bHLH-zip) DNA-binding domain. Two differ- ent USF genes, termed USF1 and USF2, are ubiquitously expressed in both humans and mice. The USF1 and USF2 proteins contain highly divergent transcriptional activation domains but share extensive homologies in the bHLH-zip region and recognize the same CACGTG DNA motifs. Al- though the DNA-binding and transcriptional activities of these proteins have been characterized, the biological function of USF is not well understood.

机译：USF是一个转录因子家族，其特征是高度保守的碱性-螺旋-环-螺旋-亮氨酸拉链（bHLH-zip）DNA结合域。在人和小鼠中普遍存在两种不同的USF基因，分别称为USF1和USF2。 USF1和USF2蛋白包含高度不同的转录激活结构域，但在bHLH-zip区具有广泛的同源性，并识别相同的CACGTG DNA基序。尽管已表征了这些蛋白质的DNA结合和转录活性，但对USF的生物学功能却知之甚少。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第3期|p.1308-1313|共6页
作者
Xu Luo; Michele Sawadogo;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer [J] . A R Clark, K Docherty, M L Read The biochemical journal . 1993,第1期

机译：螺旋-环-螺旋转录因子USF（上游刺激因子）与人胰岛素基因增强子的调控序列结合
2. The basic helix-loop-helix/Leucine zipper transcription factor USF2 integrates serum-induced PAI-1 expression and keratinocyte growth [J] . QiL., HigginsC.E., HigginsS.P., Journal of cellular biochemistry. . 2014,第10期

机译：基本的螺旋-环-螺旋/亮氨酸拉链转录因子USF2整合了血清诱导的PAI-1表达和角质形成细胞的生长
3. The helix-loop-helix containing transcription factor USF binds to and transactivates the promoter of the p53 tumor suppressor gene [J] . David Reisman, Varda Rotter Nucleic acids research . 1993,第2期

机译：含有转录因子USF的螺旋-环-螺旋与p53抑癌基因的启动子结合并反激活
4. Regulatory Module Network of Basic/Helix-loop-helix Transcription Factors During Bovine Preimplantation Development in vivo [C] . Wang Qishan, Zhu Qinglong, Pan Yuchun 2010 WASE International Conference on Information Engineering . 2010

机译：牛体内植入前发育过程中基本/螺旋环螺旋转录因子的调控模块网络。
5. Investigating the Intrinsically Disordered Regions of USF1 and Other bHlhz Transcription Factors [D] . Popa, Serban C. 2020

机译：调查USF1的本质上无序区域和其他BHLHZ转录因子
6. Antiproliferative properties of the USF family of helix-loop-helix transcription factors. [O] . X Luo, M Sawadogo 1996

机译：USF螺旋-环-螺旋转录因子家族的抗增殖特性。
7. Antiproliferative properties of the USF family of helix-loop-helix transcription factors. [O] . Luo, X, Sawadogo, M 1996

机译：USF螺旋-环-螺旋转录因子家族的抗增殖特性。

Antiproliferative properties of the USF family of helix-loop-helix transcription factors

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