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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Localization of 17β-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog
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Localization of 17β-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog

机译:雄性蛙脑中17β-羟类固醇脱氢酶的定位和睾丸激素的特征

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摘要

Several enzymes involved in the formation of steroids of the pregnene and pregnane series have been identified in the brain, but the biosynthesis of testosterone has never been reported in the central nervous system. In the present study, we have investigated the distribution and bioactivity of 17β-hydroxysteroid dehydrogenase (17β-HSD) (EC 1.1.1.62; a key enzyme that is required for the formation of testosterone and estradiol) in the brain of the male frog Rana ridibunda.
机译:在大脑中已经发现了几种与孕烯和孕烷系列甾体形成有关的酶,但是中枢神经系统从未报道过睾丸激素的生物合成。在本研究中,我们研究了雄性蛙蛙脑中17β-羟基类固醇脱氢酶(17β-HSD)(EC 1.1.1.62;形成睾丸激素和雌二醇的关键酶)的分布和生物活性。 ridibunda。

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