Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells

Gabriele Pecher; Olivera J. Finn

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Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells

机译：通过接种MUC-1 cDNA转染的爱泼斯坦-巴尔病毒永生化自体B细胞疫苗，诱导黑猩猩对人肿瘤相关抗原粘蛋白的细胞免疫

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Aberrant glycosylation of the mucin molecule (encoded by the gene MUC-1) on human epithelial cell tumors leads to the exposure of tumor-associated epitopes recognized by patients' antibodies and cytotoxic T cells. Consequently, these epitopes could be considered targets for immunother- apy. We designed a cellular vaccine, employing, instead of tumor cells, autologous Epstein-Barr virus (EBV)-immortal- ized B cells as carriers of tumor-associated mucin, to take advantage of their costimulatory molecules for T-cell activa- tion.

机译：黏蛋白分子（由基因MUC-1编码）在人上皮细胞肿瘤上的异常糖基化导致暴露于患者抗体和细胞毒性T细胞识别的肿瘤相关表位。因此，这些表位可以被认为是免疫治疗的靶标。我们设计了一种细胞疫苗，利用自身爱泼斯坦-巴尔病毒（EBV）永生化B细胞作为肿瘤相关粘蛋白的载体，而不是肿瘤细胞，以利用其共刺激分子来激活T细胞。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1699-1704|共6页
作者
Gabriele Pecher; Olivera J. Finn;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：自体独特型脉冲树突状细胞接种疫苗后，I期多发性骨髓瘤患者的细胞免疫应答诱导。
2. Solid-Phase Synthesis of a Tumor-Associated Sialyl-T_N Antigen Glycopeptide with a Partial Sequence of the "Tandem Repeat" of the MUC-1 Mucin [J] . Beate Liebe, Horst Kunz Angewandte Chemie . 1997,第6期

机译：固相合成肿瘤相关的唾液酸-T_N抗原糖肽与MUC-1粘蛋白的“串联重复”的部分序列。
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4. INDUCTION OF ANTIGEN-SPECIFIC IMMUNE RESPONSES BASED ON CHEMICAL MODIFICATION OF ANTIGEN PROTEINS TARGETING TO ANTIGEN PRESENTATING CELLS [C] . Yasuomi Yamasaki, Tomoko Ikenaga, Yoshinobu Takakura Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：基于针对抗原预增敏细胞的抗原蛋白的化学修饰，诱导抗原特异性免疫反应
5. Epstein-Barr virus nuclear antigen 3B- and 3C-regulated cellular genes in virus-immortalized B cells. [D] . Chen, Adrienne. 2007

机译：病毒永生化B细胞中爱泼斯坦巴尔病毒核抗原3B和3C调控的细胞基因。
6. Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells. [O] . G Pecher, O J Finn 1996

机译：通过接种MUC-1 cDNA转染的爱泼斯坦-巴尔病毒永生化自体B细胞疫苗诱导黑猩猩对人肿瘤相关抗原粘蛋白的细胞免疫。
7. Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells. [O] . Pecher, G, Finn, O J 1996

机译：通过接种MUC-1 cDNA转染的爱泼斯坦-巴尔病毒永生化自体B细胞疫苗，诱导黑猩猩对人肿瘤相关抗原粘蛋白的细胞免疫。
8. Induction of Immunity to a Breast Cancer Associated Mucin in Transgenic Mice Expressing the Human Antigen - A Preclinical Study [R] . Cohen, E. P. 2000

机译：表达人类抗原的转基因小鼠中乳腺癌相关粘蛋白的免疫诱导 - 临床前研究

Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells

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