A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-β

Edgar Dippel; Frank Kalkbrenner; Burghardt Wittig

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A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-β

机译：异三聚体G蛋白复合物将毒蕈碱型m1受体与磷脂酶C-β偶联

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We addressed the question as to which sub- types of G protein subunits mediate the activation of phos- pholipase C-βby the muscarinic m1 receptor. We used the rat basophilic leukemia cell line RBL-2H3-hm1 stably transfected with the human muscarinic m1 receptor cDNA. We microin- jected antisense oligonucleotides into the nuclei of the cells to inhibit selectively the expression of G protein subunits; 48 hr later muscarinic receptors were activated by carbachol, and the increase in free cytosolic calcium concentration ([Ca~2+]_i) was measured.

机译：我们解决了有关哪个G蛋白亚基亚型通过毒蕈碱型m1受体介导磷脂酶C-β激活的问题。我们使用稳定的人毒蕈碱型m1受体cDNA转染的大鼠嗜碱性白血病细胞系RBL-2H3-hm1。我们将反义寡核苷酸显微注射到细胞核中，以选择性抑制G蛋白亚基的表达。 48小时后，毒蕈碱受体被卡巴胆碱激活，并测量了游离胞质钙浓度（[Ca〜2 +] _ i）的增加。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1391-1396|共6页
作者
Edgar Dippel; Frank Kalkbrenner; Burghardt Wittig;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Effects of β-amyloid protein on M1 and M2 subtypes of muscarinic acetylcholine receptors in the medial septum-diagonal band complex of the rat: relationship with cholinergic, GABAergic, and calcium-binding protein perikarya [J] . Iván González, Juan Arévalo-Serrano, José Miguel Sanz-Anquela, Acta Neuropathologica . 2007,第6期

机译：β-淀粉样蛋白对大鼠内侧中隔-对角带复合物中毒蕈碱型乙酰胆碱受体M1和M2亚型的影响：与胆碱能，GABA能和钙结合蛋白perikarya的关系
3. Endogenous mono-ADP-ribosylation of the free Gβγ prevents stimulation of phosphoinositide 3-kinase-γ and phospholipase C-β2 and is activated by G-protein-coupled receptors [J] . Adriano MARCHEGIANI, Alexander DIETRICH, Christopher P. BERRIE, The biochemical journal . 2002,第3期

机译：游离Gβγ的内源性单ADP核糖基化阻止了磷酸肌醇3-激酶-γ和磷脂酶C-β2的刺激，并被G蛋白偶联受体激活
4. Complexing Receptor Pharmacology:Modulation of Family B G Protein—Coupled Receptor Function by RAMPs [C] . PATRICK M. SEXTON, MARIA MORFIS, NANDA TILAKARATNE, International Symposium on VIP, PACAP, and Related Peptides . 2006

机译：络合受体药理学：通过斜坡调节FALICE B G蛋白偶联受体功能
5. An in vivo biosensor for neurotransmitter release and in situ receptor activity: Acetylcholine and the M1 muscarinic receptor. [D] . Schroeder, Lee Frederick. 2009

机译：用于神经递质释放和原位受体活性的体内生物传感器：乙酰胆碱和M1毒蕈碱受体。
6. A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-beta. [O] . E Dippel, F Kalkbrenner, B Wittig, 1996

机译：异源三聚体G蛋白复合物将毒蕈碱型m1受体与磷脂酶C-β偶联。
7. A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-beta. [O] . Dippel, E, Kalkbrenner, F, Wittig, B, 1996

机译：异源三聚体G蛋白复合物将毒蕈碱型m1受体与磷脂酶C-β偶联。
8. Effects of Repeated Low-Level Sarin Exposure on Muscarinic M1 Receptor Binding, Amyloid Precursor Protein Levels and Neuropathology [R] . Roberson, M. R. , Penwell, J. K. , Reynolds, M. R. , 2005

机译：重复低水平沙林暴露对毒蕈碱m1受体结合，淀粉样蛋白前体蛋白水平和神经病理学的影响

A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-β

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