Core binding factor β- smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells

Cisca Wijmenga; Paula E. Gregory; Amitav Hajra

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Core binding factor β- smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells

机译：参与急性髓细胞白血病的核心结合因子β-平滑肌肌球蛋白重链嵌合蛋白在转化的NIH 3T3细胞中形成异常的核棒状结构

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Patients with the M4Eo subtype of acute myeloid leukemia almost invariably are found to have an inversion of chromosome 16 in their leukemic cells, which results in a gene fusion between the transcription factor called core binding factor β (CBFβ) on 16q and a smooth muscle myosin heavy chain (SMMHC) gene on 16p. Subcellular localizations of the wild-type CBFβand the CBFβ-SMMHC fusion protein were determined by immunofluorescence of NIH 3T3 cells that overexpress wild-type or fusion protein. Normal CBFβshowed an unexpected perinuclear pattern consistent with primary localization in the Golgi complex.

机译：患有急性髓性白血病M4Eo亚型的患者几乎总是发现其白血病细胞中的16号染色体发生倒位，这导致16q上称为核心结合因子β（CBFβ）的转录因子与平滑肌肌球蛋白之间发生基因融合16p上的重链（SMMHC）基因。通过过表达野生型或融合蛋白的NIH 3T3细胞的免疫荧光测定野生型CBFβ和CBFβ-SMMHC融合蛋白的亚细胞定位。正常的CBFβ表现出意想不到的核周模式，与高尔基复合体的主要定位一致。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1630-1635|共6页
作者
Cisca Wijmenga; Paula E. Gregory; Amitav Hajra;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. The leukemic core binding factor β-smooth muscle myosin heavy chain (CBFβ-SMMHC) chimeric protein requires both CBFβ and myosin heavy chain domains for transformation of NIH 3T3 cells [J] . AMITAV hAJRA, PU P. LIU, QING WANG, Proceedings of the National Academy of Sciences of the United States of America . 1995,第6期

机译：白血病核心结合因子β-平滑肌肌球蛋白重链（CBFβ-SMMHC）嵌合蛋白需要CBFβ和肌球蛋白重链结构域才能转化NIH 3T3细胞
2. Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein. [J] . A Hajra, P P Liu, N A Speck, Molecular and Cellular Biology . 1995,第9期

机译：核心结合因子α（CBF alpha）的过表达逆转了CBFβ-平滑肌肌球蛋白重链嵌合癌蛋白的细胞转化。
3. The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor beta1 in vascular smooth muscle cells. [J] . Williams C, Brown XQ, Bartolak Suki E, Biomaterials . 2011,第2期

机译：使用微模式控制平滑肌肌球蛋白重链表达并限制对血管平滑肌细胞中转化生长因子beta1的响应。
4. Cytotoxic Effects of Transforming Growth Factor-α Conjugated with Cytotoxin Saporin on proliferating vascular smooth muscle cells [C] . Yang Jun, Chu Chun, Deng Biao, International Conference on Materials Science and Manufacturing . 2013

机译：将生长因子 - α与细胞毒素Saporin缀合在增殖血管平滑肌细胞中的细胞毒性作用
5. Part I: Structural and functional insight into the type A CBFbeta-SMMHC protein and acute myeloid leukemia (AML). Part II: Solution structure of the HDGF PWWP domain and implications of its function as a DNA binding domain. [D] . Lukasik, Stephen Michael. 2006

机译：第一部分：对A型CBFbeta-SMMHC蛋白和急性髓细胞性白血病（AML）的结构和功能洞察。第二部分：HDGF PWWP域的溶液结构及其作为DNA结合域的功能的含义。
6. Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells. [O] . C Wijmenga, P E Gregory, A Hajra, 1996

机译：参与急性髓性白血病的核心结合因子β-平滑肌肌球蛋白重链嵌合蛋白在转化的NIH 3T3细胞中形成异常的核棒状结构。
7. Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells. [O] . Wijmenga, C, Gregory, P E, Hajra, A, 1996

机译：参与急性髓细胞白血病的核心结合因子β-平滑肌肌球蛋白重链嵌合蛋白在转化的NIH 3T3细胞中形成异常的核棒状结构。

Core binding factor β- smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells

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