Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCγ, Crk, and Grb2

Andrew B. Sparks; James E. Rider; Noah G. Hoffman

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Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCγ, Crk, and Grb2

机译：来自Src，Yes，Abl，Cortactin，p53bp2，PLCγ，Crk和Grb2的Src同源3域的不同配体偏好

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Src homology 3 (SH3) domains are con- served protein modules 50-70 amino acids long found in a variety of proteins with important roles in signal transduc- tion. These domains have been shown to mediate protein- protein interactions by binding short proline-rich regions in ligand proteins. However, the ligand preferences of most SH3 domains and the role of these preferences in regulating SH3-mediated protein-protein interactions remain poorly defined.

机译：Src同源性3（SH3）域是50-70个氨基酸的蛋白质模块，长期存在于多种蛋白质中，这些蛋白质在信号转导中具有重要作用。已经显示这些结构域通过结合配体蛋白中富含脯氨酸的短区域来介导蛋白-蛋白相互作用。但是，大多数SH3域的配体偏好和这些偏好在调节SH3介导的蛋白质-蛋白质相互作用中的作用仍然定义不清。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1540-1544|共5页
作者
Andrew B. Sparks; James E. Rider; Noah G. Hoffman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Antagonists of the Src homology 2 (SH2) domains of Grb2, Src, Lck and ZAP-70. [J] . Garcia-Echeverria C, Garcia-Echeverria C Current medicinal chemistry . 2001,第13期

机译：Grb2，Src，Lck和ZAP-70的Src同源2（SH2）域的拮抗剂。
2. Antagonists of the Src Homology 2 (SH2) Domains of Grb2, Src, Lck and ZAP-70 [J] . Carlos García-Echeverría Current Medicinal Chemistry . 2001,第13期

机译：Grb2，Src，Lck和ZAP-70的Src同源2（SH2）域的拮抗剂
3. Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation [J] . J Zheng, K Machida, S Antoku, Oncogene . 2010,第48期

机译：结合CrkI的Src同源性3结构域的蛋白质在Crk转化中具有独特的作用
4. Design of Phosphotyrosine Mimetics Targeting the Src Homology 2 Domain-Containing Phosphatase 1 (SHP-1) Non-Receptor Binding Site [C] . Kulis C., Bourne G.T., Kellie S. International Peptide Symposium . 2009

机译：靶向含SRC同源性2结构域的磷酸酶1（SHP-1）非受体结合位点的磷酸吡塞胺模拟物的设计
5. Disulfide Bridging the Gap between Src and Cortactin: A New Paradigm in SH2 Domain-mediated Signaling. [D] . Evans, Jason VanBuren. 2013

机译：二硫键弥合Src和Cortactin之间的差距：SH2域介导的信号传导的新范式。
6. Distinct ligand preferences of Src homology 3 domains from Src Yes Abl Cortactin p53bp2 PLCgamma Crk and Grb2. [O] . A B Sparks, J E Rider, N G Hoffman, 1996

机译：来自SrcYesAblCortactinp53bp2PLCgammaCrk和Grb2的Src同源3域的不同配体偏好。
7. Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2. [O] . Sparks, A B, Rider, J E, Hoffman, N G, 1996

机译：来自Src，Yes，Abl，Cortactin，p53bp2，PLCgamma，Crk和Grb2的Src同源3域的不同配体偏好。

Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCγ, Crk, and Grb2

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