Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in Swiss 3T3 and HT-29 cell lines

Felipe F. Casanueva; Francisco R. Perez; Xesus Casabiell

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Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in Swiss 3T3 and HT-29 cell lines

机译：蛙皮素拮抗剂对Swiss 3T3和HT-29细胞系细胞增殖和细胞内钙浓度的影响之间的相关性

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Bombesin (BN) acts as an autocrine mitogen in various human cancers. Several pseudononapeptide BN- (6-14) analogs with a reduced peptide bond between positions 13 and 14 have been shown to suppress the mitogenic activity of BN or gastrin-releasing peptide (GRP) when assessed by radioreceptor or proliferation assays and may have significant clinical applications. The search for potent and safe BN antagonists requires the evaluation of a large series of analogs in radioreceptor and proliferation assays.

机译：Bombesin（BN）在多种人类癌症中起自分泌促分裂原的作用。当通过放射受体或增殖分析评估时，已显示几种在位置13和14之间具有减少的肽键的伪九肽BN-（6-14）类似物可抑制BN或胃泌素释放肽（GRP）的促有丝分裂活性，并且可能具有重要的临床意义应用程序。寻找有效和安全的BN拮抗剂需要在放射受体和增殖分析中评估一系列类似物。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第4期|p.1406-1411|共6页
作者
Felipe F. Casanueva; Francisco R. Perez; Xesus Casabiell;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. JMV641: a potent bombesin receptor antagonist that inhibits Swiss 3T3 cell proliferation. [J] . Azay J, Gagne D, Devin C, Regulatory peptides. . 1996,第1期

机译：JMV641：一种有效的蛙皮素受体拮抗剂，可抑制Swiss 3T3细胞增殖。
2. EFFECTS OF PDGF-BB ON INTRACELLULAR CALCIUM CONCENTRATION AND PROLIFERATION IN CULTURED GLOMERULAR MESANGIAL CELLS [J] . WEN Li-ping, ZHANG Chong, BIAN Fan, Journal of Shanghai Second Medical University . 2006,第2期

机译：PDGF-BB对培养的肾小球系膜细胞内钙离子浓度和增殖的影响
3. Effects of endothelin-1 on hepatic stellate cell proliferation, collagen synthesis and secretion, intracellular free calcium concentration [J] . Chuan-Yong Guo, Jian-Ye Wu, Yun-Bin Wu, World Journal of Gastroenterology . 2004,第18期

机译：内皮素-1对肝星状细胞增殖，胶原蛋白合成和分泌，细胞内游离钙浓度的影响
4. Effects of 50Hz Homogeneous Ferromagnetic Field on the Concentrations of Intracellular Calcium-ion of SNU Cells and Lymphma Cells In Vitro [C] . Hongyong Guo, Lingxiao Xing, Mo Zheng, . 2005

机译：50Hz均匀铁磁场对SNU细胞和淋巴细胞体外细胞内钙离子浓度的影响
5. The effects of sodium chloride stress upon the transport of calcium in roots of Hordeum vulgare and intracellular ion concentrations in root hairs of Arabidopsis thaliana. [D] . Halperin, Stephen Julius. 2000

机译：氯化钠胁迫对大麦根中钙转运和拟南芥根毛中细胞内离子浓度的影响。
6. Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in Swiss 3T3 and HT-29 cell lines. [O] . F F Casanueva, F R Perez, X Casabiell, 1996

机译：蛙皮素拮抗剂对瑞士3T3和HT-29细胞系中细胞增殖与细胞内钙浓度的影响之间的相关性。
7. Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in Swiss 3T3 and HT-29 cell lines. [O] . Casanueva, F F, Perez, F R, Casabiell, X, 1996

机译：蛙皮素拮抗剂对瑞士3T3和HT-29细胞系中细胞增殖与细胞内钙浓度的影响之间的相关性。
8. Extracellular ATP Induces the Release of Calcium from Intracellular Stores without the Activation of Protein Kinase C in Swiss 3T6 Mouse Fibroblasts. [R] . McCarty, R. E., Gonzalez, F. A., Rozengurt, E., 1989

机译：在瑞士3T6小鼠成纤维细胞中，细胞外aTp诱导钙从细胞内储存中释放而不激活蛋白激酶C.

Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in Swiss 3T3 and HT-29 cell lines

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