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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >E2F1 and E1A_12S have a homologous activation domain regulated by RB and CBP
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E2F1 and E1A_12S have a homologous activation domain regulated by RB and CBP

机译：E2F1和E1A_12S具有由RB和CBP调节的同源激活域

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摘要

The E2F1 transcription factor has a well- characterized activation domain at its C terminus and the E1A protein has a recently defined activation domain at its N terminus. Here we show that these activation domains are highly related in sequence. The sequence homology reflects, at least partly, the conservation of common binding sites for the RB and CBP/p300 proteins, which are preserved in the same relative order along E2F1 and E1A. Furthermore, the inter- action of RB and CBP with these two activation domains results in the same functional consequences: RB represses both activation domains, whereas CBP stimulates them.
机译：E2F1转录因子在其C末端具有特征明确的激活域，而E1A蛋白在其N末端具有最近定义的激活域。在这里，我们显示了这些激活域在序列上高度相关。序列同源性至少部分反映了RB和CBP / p300蛋白的共同结合位点的保守性，它们沿E2F1和E1A以相同的相对顺序保留。此外，RB和CBP与这两个激活域的相互作用导致相同的功能后果：RB抑制两个激活域，而CBP刺激它们。

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