Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease

Subhransu K. Ray; Chaim Putterman; Betty Diamond

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Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease

机译：在对外源抗原的应答过程中通常会产生致病性自身抗体：自身免疫疾病的范例

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The immune system's ability to distinguish self and nonself is essential for both host defense against foreign agents and protection of self-antigens from autoim- mune destruction. Such discrimination is complicated by extensive structural homology shared between foreign and self antigens. One hypothesis to explain the development of an autoimmune response is that some B cells activated by foreign antigen acquire, through somatic mutation, specificity for both the eliciting foreign antigen and self antigen.

机译：免疫系统区分自身和非自身的能力对于宿主防御外来因子和保护自身抗原免于自身免疫破坏都是至关重要的。外源和自身抗原之间广泛的结构同源性使这种区分变得复杂。一种解释自身免疫反应发展的假说是，一些被外源抗原激活的B细胞通过体细胞突变获得了对引起外源抗原和自身抗原的特异性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.2019-2024|共6页
作者
Subhransu K. Ray; Chaim Putterman; Betty Diamond;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. [O] . S K Ray, C Putterman, B Diamond 1996

机译：病原性自身抗体通常是在对外源抗原的反应过程中产生的：自身免疫性疾病的范例。
7. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. [O] . Ray, S K, Putterman, C, Diamond, B 1996

机译：病原性自身抗体通常是在对外来抗原的反应过程中产生的：自身免疫性疾病的范例。

Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease

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