The catalytic mechanism of β-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

Christian Damblon; Xavier Raquet; Lu-Yun Lian

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The catalytic mechanism of β-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

【24h】

The catalytic mechanism of β-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

机译：β-内酰胺酶的催化机理：TEM-1酶活性位点赖氨酸残基的NMR滴定

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

β-Lactamases are widespread in the bacte- rial world, where they are responsible for resistance to pen- icillins, cephalosporins, and related compounds, currently the most widely used antibacterial agents. Detailed structural and mechanistic understanding of these enzymes can be expected to guide the design of new antibacterial compounds resistant to their action. A number of high-resolution structures are available for class A β-lactamases, whose catalytic mechanism involves the acylation of a serine residue at the active site.

机译：β-内酰胺酶在细菌界很普遍，它们对青霉素，头孢菌素和相关化合物（目前使用最广泛的抗菌剂）产生抗性。可以预期对这些酶的详细结构和机理的理解将指导对它们的作用具有抗性的新抗菌化合物的设计。 A类β-内酰胺酶具有许多高分辨率结构，其催化机制包括在活性位点丝氨酸残基的酰化。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.1747-1752|共6页
作者
Christian Damblon; Xavier Raquet; Lu-Yun Lian;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. The Catalytic Mechanism of Glucose 6-Phosphate Dehydrogenases: Assignment and (1)H NMR Spectroscopy pH Titration of the Catalytic Histidine Residue in the 109 kDa Leuconostoc mesenteroides Enzyme. [J] . Cosgrove MS, Loh SN, Ha JH, Biochemistry . 2002,第22期

机译：葡萄糖6-磷酸脱氢酶的催化机理：109 kDa肠膜十二指肠副肠球菌中酶组氨酸残基的赋值和（1）NMR光谱pH滴定。
2. The Roles of Active-Site Residues in the Catalytic Mechanism of trans-3-Chloroacrylic Acid Dehalogenase:A Kinetic,NMR,and Mutational Analysis [J] . Hugo F.Azurmendi, Susan C.Wang, Michael A.Massiah, Biochemistry . 2004,第14期

机译：活性位点残留在反式 - 3-氯丙烯酸脱氢酶催化机制中的作用：动力学，NMR和突变分析
3. Characterization of the active-site residues asparagine 167 and lysine 161 of the IMP-1 metallo beta-lactamase [J] . Haruta S., Eriguchi Y., Sawai T., FEMS Microbiology Letters . 2001,第1期

机译：IMP-1金属β-内酰胺酶活性位点天冬酰胺167和赖氨酸161的表征
4. NMR models of the angiotensin-I converting Enzyme Zn(II)catalytic sites:The basis for a structural study on the enzyme-substrate interaction [C] . Georgios A.Spyroulias, Athanassios S.Galanis, Georgios Pairas International Peptide Symposium;European Peptide Symposium . 2005

机译：血管紧张素-I转化酶Zn（II）催化位点的NMR模型：对酶 - 底物相互作用的结构研究的基础
5. Exploring the catalytic mechanisms and physiological function of senescence marker protein 30 via crystallography, enzyme kinetics, and isothermal titration calorimetry. [D] . Scott, Stephanie Helen. 2013

机译：通过晶体学，酶动力学和等温滴定量热法研究衰老标记蛋白30的催化机理和生理功能。
6. The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme. [O] . C Damblon, X Raquet, L Y Lian, 1996

机译：β-内酰胺酶的催化机理：TEM-1酶活性位点赖氨酸残基的NMR滴定。
7. The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme. [O] . Damblon, C, Raquet, X, Lian, L Y, 1996

机译：β-内酰胺酶的催化机理：TEM-1酶活性位点赖氨酸残基的NMR滴定。
8. Essentiality of the Active-Site Arginine Residue for the Normal Catalytic Activity of Cu, Zn Superoxide Dismutase [R] . Borders, C. L., Saunders, J. E., Blech, D. M., 1985

机译：活性位点精氨酸残留对Cu，Zn超氧化物歧化酶正常催化活性的影响

The catalytic mechanism of β-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

摘要

著录项

相似文献

相关主题

期刊订阅