A targeted mutation of the D_3 dopamine receptor gene is associated with hyperactivity in mice

Domenico Accili; C. Simone Fishburn; John Drago

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A targeted mutation of the D_3 dopamine receptor gene is associated with hyperactivity in mice

机译：D_3多巴胺受体基因的定向突变与小鼠活动过度有关

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While most effects of dopamine in the brain are mediated by the D_1 and D_2 receptor subtypes, other members of this G protein-coupled receptor family have potentially important functions. D_3 receptors belong to the D_2-like subclass of dopamine receptors, activation of which inhibits adenylyl cyclase. Using targeted mutagenesis in mouse embryonic stem cells, we have generated mice lacking functional D_3 receptors.

机译：尽管脑中多巴胺的大多数作用是由D_1和D_2受体亚型介导的，但该G蛋白偶联受体家族的其他成员具有潜在的重要功能。 D_3受体属于多巴胺受体的D_2样亚类，其激活抑制腺苷酸环化酶。使用小鼠胚胎干细胞中的定向诱变，我们已经生成了缺乏功能性D_3受体的小鼠。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.1945-1949|共5页
作者
Domenico Accili; C. Simone Fishburn; John Drago;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. [O] . D Accili, C S Fishburn, J Drago, 1996

机译：D3多巴胺受体基因的定向突变与小鼠活动过度有关。
7. A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. [O] . Accili, D, Fishburn, C S, Drago, J, 1996

机译：D3多巴胺受体基因的定向突变与小鼠活动过度有关。

A targeted mutation of the D_3 dopamine receptor gene is associated with hyperactivity in mice

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