Two-hybrid system as a model to study the interaction of β -amyloid peptide monomers

Stephen R. Hughes; Shefali Goyal; Jeannie E. Sun

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Two-hybrid system as a model to study the interaction of β -amyloid peptide monomers

机译：以双杂交体系为模型研究β-淀粉样肽单体的相互作用

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The kinetics of amyloid fibril formation by β-amyloid peptide (Aβ) are typical of a nucleation-dependent polymerization mechanism. This type of mechanism suggests that the study of the interaction of Aβwith itself can provide some valuable insights into Alzheimer disease amyloidosis. Interaction of Aβwith itself was explored with the yeast two-hybrid system.

机译：β-淀粉样肽（Aβ）形成淀粉样原纤维的动力学是成核依赖性聚合机制的典型特征。这种类型的机制表明，对Aβ与自身相互作用的研究可以为阿尔茨海默氏病淀粉样变性提供一些有价值的见解。利用酵母双杂交系统探索了Aβ与自身的相互作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.2065-2070|共6页
作者
Stephen R. Hughes; Shefali Goyal; Jeannie E. Sun;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Study of a monomer-monomer reaction system with short-range repulsive interactions - Monomer-monomer reaction system with repulsive interactions [J] . Sanservino MA, Lopez A, Albano EV, The European physical journal, B. Condensed matter physics . 2004,第3期

机译：具有短程排斥相互作用的单体-单体反应体系的研究-具有排斥相互作用的单体-单体反应体系
2. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins. [J] . Harnasch M, Grau S, Behrends C, Molecular membrane biology . 2004,第6期

机译：早老素-淀粉样蛋白前体相互作用的表征使用细菌表达和人类膜蛋白的两个杂交系统。
3. Protein-peptide interactions analyzed with the yeast two-hybrid system. [J] . Yang M, Wu Z, Fields S Nucleic Acids Research . 1995,第7期

机译：用酵母双杂交系统分析蛋白质-肽的相互作用。
4. Aggregation studies of beta-amyloid 25-35 fragment in interaction with other modified beta-amyloid peptide fragments [C] . Lukasz P.Frankiewicz, Wiktor Banachewicz, Aleksandra Misicka International Peptide Symposium;European Peptide Symposium . 2005

机译：与其他改性β-淀粉样蛋白肽片段相互作用β-淀粉样蛋白25-35片段的聚集研究
5. Using Small Molecules and Peptides as Chemical Tools to Study Metal-Amyloid, Membrane-Amyloid, and Peptide-Amyloid Interactions. [D] . Pithadia, Amit S. 2016

机译：使用小分子和肽作为化学工具研究金属淀粉样蛋白，膜淀粉样蛋白和肽淀粉样蛋白相互作用。
6. Two-hybrid system as a model to study the interaction of beta-amyloid peptide monomers. [O] . S R Hughes, S Goyal, J E Sun, 1996

机译：以双杂交系统为模型研究β-淀粉样肽单体的相互作用。
7. Two-hybrid system as a model to study the interaction of beta-amyloid peptide monomers. [O] . Hughes, S R, Goyal, S, Sun, J E, 1996

机译：以双杂交系统为模型，研究β-淀粉样肽单体的相互作用。

Two-hybrid system as a model to study the interaction of β -amyloid peptide monomers

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