Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

Teresa G. Hastings; David A. Lewis; Michael J. Zigmond

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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

机译：氧化在纹状体多巴胺注射液神经毒性作用中的作用

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We have examined the biochemical and his- tological effects of high concentrations of dopamine (0.05-1.0 μmol) injected into the rat striatum. Twenty-four hours after such injections, the oxidation products of dopamine and dihydroxyphenylacetic acid were detected as both free and protein-bound cysteinyl dopamine and cysteinyl dihydroxy- phenylacetic acid. Protein-bound cysteinyl catechols were increased 7- to 20-fold above control tissue levels.

机译：我们检查了注入大鼠纹状体中的高浓度多巴胺（0.05-1.0μmol）的生化和组织学作用。注射后二十四小时，检测到多巴胺和二羟基苯基乙酸的氧化产物为游离的和结合蛋白的半胱氨酰多巴胺和半胱氨酰二羟基苯基乙酸。与蛋白质结合的半胱氨酰儿茶酚比对照组织水平提高了7至20倍。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.1956-1961|共6页
作者
Teresa G. Hastings; David A. Lewis; Michael J. Zigmond;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：帕金森早期6-羟基二甲胺模型对大鼠中脑多巴胺神经元的单侧脑内血红蛋白模型的影响：立体学研究
6. Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections. [O] . T G Hastings, D A Lewis, M J Zigmond 1996

机译：氧化在纹状体内注射多巴胺的神经毒性作用中的作用。
7. Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections. [O] . Hastings, T G, Lewis, D A, Zigmond, M J 1996

机译：氧化在纹状体内注射多巴胺的神经毒性作用中的作用。
8. Nigrostriatal Dopamine System and Methamphetamine: Roles for Excitotoxicity and Environmental, Metabolic and Oxidative Stress. [R] . Yamamoto, B. 2005

机译：黑质纹状体多巴胺系统和甲基苯丙胺：兴奋性毒性和环境，代谢和氧化应激的作用。

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

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