Single-amino acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate synthase

Jonathan M. Shaver; Douglas C. Bittel; Janita M. Sellner

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Single-amino acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate synthase

机译：单氨基酸取代消除了赖氨酸对玉米二氢二吡啶甲酸合酶的抑制作用

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Dihydrodipicolinate synthase (DHPS; EC 4.2.1.52) catalyzes the first step in biosynthesis of lysine in plants and bacteria. DHPS in plants is highly sensitive to end-product inhibition by lysine and, therefore, has an im- portant role in regulating metabolite flux into lysine. To better understand the feedback inhibition properties of the plant enzyme, we transformed a maize cDNA for lysine-sensitive DHPS into an Escherichia coli strain lacking DHPS activity.

机译：二氢二吡啶甲酸合酶（DHPS; EC 4.2.1.52）催化植物和细菌中赖氨酸生物合成的第一步。植物中的DHPS对赖氨酸对终产物的抑制高度敏感，因此在调节代谢物向赖氨酸的通量中起着重要的作用。为了更好地了解植物酶的反馈抑制特性，我们将赖氨酸敏感的DHPS的玉米cDNA转化为缺乏DHPS活性的大肠杆菌。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.1962-1966|共5页
作者
Jonathan M. Shaver; Douglas C. Bittel; Janita M. Sellner;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Tyrosine 110 Plays a Critical Role in Regulating the Allosteric Inhibition of Campylobacter jejuni Dihydrodipicolinate Synthase by Lysine [J] . Conly Cuyiar J. T., Skovpen Yulia V., Li Shuo, Biochemistry . 2014,第47期

机译：酪氨酸110在调节赖氨酸的调节弯曲杆菌二水二硫代啶氨基吡啶鎓合成酶的变构抑制方面发挥着关键作用
2. Dihydrodipicolinate synthase from Escherichia coli: pH dependent changes in the kinetic mechanism and kinetic mechanism of allosteric inhibition by L-lysine. [J] . Karsten WE Biochemistry . 1997,第7期

机译：大肠杆菌的二氢二吡啶甲酸合酶：pH依赖性变化的动力学机制和L-赖氨酸变构抑制的动力学机制。
3. Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues [J] . Priyanka Shrivastava, Vikas Navratna, Yumnam Silla, Scientific reports. . 2016,第1期

机译：用α-酮丙酸及其其他结构类似物抑制结核分枝杆菌二氢化纤维素苷酸盐的合酶
4. SUBSTITUTED AMINO ACIDS AS INHIBITORS OF ACETOHYDROXY ACID SYNTHASE [C] . J.L. Huppatz, J.E. Casida International Congress of Pesticide Chemistry . 1986

机译：取代氨基酸作为乙酰羟基酸合酶的抑制剂
5. Mechanistic and inhibition studies of 4-amino-4-deoxychorismate synthase, anthranilate synthase, isochorismate synthase and salicylate synthase. [D] . Ziebart, Kristin Therese. 2010

机译：4-氨基-4-脱氧胆酸合酶，邻氨基苯甲酸酯合酶，异丁烯酸合酶和水杨酸酯合酶的机理和抑制研究。
6. Single-amino acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate synthase. [O] . J M Shaver, D C Bittel, J M Sellner, 1996

机译：单氨基酸取代消除了赖氨酸对玉米二氢二吡啶甲酸合酶的抑制作用。
7. Single-amino acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate synthase. [O] . Shaver, J M, Bittel, D C, Sellner, J M, 1996

机译：单氨基酸取代消除了赖氨酸对玉米二氢二吡啶甲酸合酶的抑制作用。

Single-amino acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate synthase

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