An ATP-dependent As(III)-glutathione transport system in membrane vesic les of Leishmania tarentolae

Saibal Dey; Marc Ouellette; James Lightbody

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An ATP-dependent As(III)-glutathione transport system in membrane vesic les of Leishmania tarentolae

机译：塔氏Leishmania tarentolae膜囊泡中依赖ATP的As（III）-谷胱甘肽转运系统

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Membrane preparations enriched in plasma membrane vesicles prepared from promastigotes of Leishma- nia tarentolae were shown to accumulate thiolate derivatives of ~73As(III). Free arsenite was transported at a low rate, but rapid accumulation was observed after reaction with reduced glutathione (GSH), conditions that favor the formation of As(GS)_3. Accumulation required ATP but not electrochemical energy, indicating that As(GS)_3 is transported by an ATP- coupled pump.

机译：从塔氏疟原虫的前鞭毛体制备的富含质膜囊泡的膜制剂显示出积累了〜73As（III）的硫醇盐衍生物。游离亚砷酸盐的迁移率较低，但是在与还原型谷胱甘肽（GSH）反应后观察到快速积累，条件是有利于As（GS）_3的形成。积累需要ATP，但不需要电化学能，这表明As（GS）_3是由ATP耦合泵输送的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.2192-2197|共6页
作者
Saibal Dey; Marc Ouellette; James Lightbody;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：鼠肝小管质膜囊泡中7beta，8alpha-dihydroxy-9alpha，10alpha-oxy-7,8,9,10-tetrahydrobenzo（a）pyrene的谷胱甘肽共轭物的ATP依赖性运输。
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6. An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. [O] . S Dey, M Ouellette, J Lightbody, 1996

机译：塔氏Leishmania tarentolae膜囊泡中的ATP依赖性As（III）-谷胱甘肽转运系统。
7. An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae. [O] . Dey, S, Ouellette, M, Lightbody, J, 1996

机译：塔氏Leishmania tarentolae膜囊泡中的ATP依赖性As（III）-谷胱甘肽转运系统。

An ATP-dependent As(III)-glutathione transport system in membrane vesic les of Leishmania tarentolae

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