Spectrum of HERG K~+-channel dysfunction in an inherited cardiac arrhythmia

Michael C. Sanguinetti; Mark E. Curran

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Spectrum of HERG K~+-channel dysfunction in an inherited cardiac arrhythmia

机译：遗传性心律不齐中HERG K〜+通道功能障碍的光谱

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Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K~+-channel gene, cause chromosome 7-linked LQT. Heter- ologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characterized cardiac delayed rectifier K+ current, I_Kr, and led to the hypothesis that mutations in HERG reduced I_Kr, causing prolonged myocel- lular action potentials.

机译：长QT综合征（LQT）是常染色体显性遗传疾病，可导致因心律不齐而突然死亡。我们最近发现，HERG（一种K〜+通道基因）中的突变会导致与7号染色体相关的LQT。 HERG在非洲爪蟾卵母细胞中的异源表达表明，HERG电流与特征明确的心脏延迟整流器K +电流I_Kr相似，并得出了这样的假设，即HERG突变会降低I_Kr，从而延长心肌的动作电位。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.2208-2212|共5页
作者
Michael C. Sanguinetti; Mark E. Curran;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：抗成瘾药物伊博加因抑制hERG通道：心律失常的风险
2. hERG (KCNH2 or Kv11.1) K+ channels: screening for cardiac arrhythmia risk. [J] . Bowlby MR, Peri R, Zhang H, Current drug metabolism . 2009,第9期

机译：hERG（KCNH2或Kv11.1）K +通道：筛查心律失常的风险。
3. hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk [J] . Mark R. Bowlby Ravi Peri Howard Zhang John Dunlop Current Drug Metabolism . 2008,第9期

机译：hERG（KCNH2或Kv11.1）K +通道：筛查心脏心律失常风险
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5. Evaluation of Clinical Practices and Needs about Variants of Uncertain Significance Results in Inherited Cardiac Arrhythmia and Inherited Cardiomyopathy Genes [D] . Muller, Reka D. 2019

机译：对遗传性心律失常和遗传性心肌病基因的不确定意义变异的评估和对临床实践的评价
6. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. [O] . M C Sanguinetti, M E Curran, P S Spector, 1996

机译：遗传性心律失常中HERG K +通道功能障碍的频谱。
7. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. [O] . Sanguinetti, M C, Curran, M E, Spector, P S, 1996

机译：遗传性心律失常中HERG K +通道功能障碍的频谱。

Spectrum of HERG K~+-channel dysfunction in an inherited cardiac arrhythmia

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